-
Paracetamol sensing with a pencil lead electrode modified with carbon nanotubes and polyvinylpyrrolidone
- Back
Document Title
Paracetamol sensing with a pencil lead electrode modified with carbon nanotubes and polyvinylpyrrolidone
Author
Pinyou P., Blay V., Chansaenpak K., Lisnund S.
Name from Authors Collection
Affiliations
Institute of Science, School of Chemistry, Suranaree University of Technology, 111 University Avenue, Suranaree, Muang, Nakhon Ratchasima, 30000, Thailand; Division of Biomaterials and Bioengineering, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, United States; National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, Thailand; Department of Applied Chemistry, Faculty of Science and Liberal Arts, Rajamangala University of Technology Isan, 744, Suranarai Rd., Nakhon Ratchasima, 30000, Thailand
Type
Article
Source Title
Chemosensors
ISSN
22279040
Year
2020
Volume
8
Issue
4
Page
Jan-13
Open Access
Gold
Publisher
MDPI AG
DOI
10.3390/chemosensors8040133
Abstract
The determination of paracetamol is a common need in pharmaceutical and environmental samples for which a low-cost, rapid, and accurate sensor would be highly desirable. We develop a novel pencil graphite lead electrode (PGE) modified with single-wall carbon nanotubes (SWCNTs) and polyvinylpyrrolidone (PVP) polymer (PVP/SWCNT/PGE) for the voltammetric quantification of paracetamol. The sensor shows remarkable analytical performance in the determination of paracetamol at neutral pH, with a limit of detection of 0.38 µM and a linear response from 1 to 500 µM using square-wave voltammetry (SWV), which are well suited to the analysis of pharmaceutical preparations. The introduction of the polymer PVP can cause dramatic changes in the sensing performance of the electrode, depending on its specific architecture. These effects were investigated using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM). The results indicate that the co-localization and dispersion of PVP throughout the carbon nanotubes on the electrode are key to its superior electrochemical performance, facilitating the electrical contact between the nanotubes and with the electrode surface. The application of this sensor to commercial syrup and tablet preparations is demonstrated with excellent results. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Funding Sponsor
Office of the Higher Education Commission; Thailand Research Fund; National Nanotechnology Center
License
CC BY
Rights
Author
Publication Source
Scopus
Note
Full text
Document
-
Paracetamol sensing with a pencil lead electrode modified with carbon nanotubes and polyvinylpyrrolidoneDownload