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Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis
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Metadata
Document Title
Polymorphisms in drug-resistant-related genes shared among drug-resistant and pan-susceptible strains of sequence type 10, Beijing family of Mycobacterium tuberculosis
Author
Regmi S.M., Coker O.O., Kulawonganunchai S., Tongsima S., Prammananan T., Viratyosin W., Thaipisuttikul I., Chaiprasert A.
Name from Authors Collection
Affiliations
Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand
Type
Article
Source Title
International Journal of Mycobacteriology
ISSN
22125531
Year
2015
Volume
4
Issue
1
Page
67-72
Open Access
Gold
Publisher
Elsevier Ltd
DOI
10.1016/j.ijmyco.2014.11.050
Abstract
Mutations in genes involved in drug metabolism have been well-associated with drug resistance. Sequence analysis of known antimycobacterial drug-resistant genes is often used to predict resistance to antibiotics. However, some polymorphisms in such genes may serve a phylogenetic purpose rather than resistance to drugs. The Beijing family of Mycobacterium tuberculosis (MTB) is prevalent worldwide and has been associated with the emergence of multidrug resistance. Sequence type (ST) 10 of the Beijing family is the most predominant in countries like Peru, Taiwan and Thailand.A sequence analysis was performed of 81 previously reported drug-resistant associated genes in multidrug-resistant and pan-susceptible strains of the Beijing family sequence type 10 of MTB. This analysis revealed 10 synonymous and 12 nonsynonymous single nucleotide polymorphisms (SNPs) that are shared by all strains under study. One frameshift mutation was also observed to be common to all. These data might be useful in excluding some observed SNPs in drug-resistant-associated genes of MTB Beijing ST 10 when performing genotypic drug susceptibility assay. © 2015 Asian African Society for Mycobacteriology.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
Japan Science and Technology Agency; Mahidol University; National Science and Technology Development Agency; Faculty of Medicine Siriraj Hospital, Mahidol University
License
CC BY
Rights
Author
Publication Source
Scopus