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Comparative genome analysis between Southeast Asian and South American Zika viruses
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Metadata
Document Title
Comparative genome analysis between Southeast Asian and South American Zika viruses
Author
Kochakarn T., Kotanan N., Kümpornsin K., Loesbanluechai D., Thammasatta M., Auewarakul P., Wilairat P., Chookajorn T.
Name from Authors Collection
Affiliations
Genomics and Evolutionary Medicine Unit, Centre of Excellence in Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand; Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University Bangkok, Thailand; National Science and Technology Development AgencyPathum Thani, Thailand; Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Type
Article
Source Title
Asian Pacific Journal of Tropical Medicine
ISSN
19957645
Year
2016
Volume
9
Issue
11
Page
1048-1054
Open Access
Gold
Publisher
Elsevier (Singapore) Pte Ltd
DOI
10.1016/j.apjtm.2016.10.002
Abstract
Objective To understand the cause for the differences between potentially mild Southeast Asian and the more pathogenic ZIKV in South America. Methods A comparative genomic analysis was performed to determine putative causations stemming from ZIKV. Results Phylogenetic analyses integrating geographical and time factors revealed that Southeast Asian ZIKV might not be the direct source of South American outbreaks as previously speculated. Amino acid residues unique to South American ZIKV isolates at the envelope, pr and NS1 proteins are listed and shown in the structural context. These unique residues on external viral proteins are not found in Southeast Asian ZIKV and could be responsible for the ongoing outbreak either via an intrinsic property of the virus or interactions with human immunity. Only a selected few primer/probe sets currently in clinical use were identified of being capable of detecting ZIKV strains worldwide. The envelope proteins of dengue virus (DENV) and ZIKV also showed a remarkable degree of similarity especially at the surface residues. Conclusions These findings may help explain the cross-reactivity of DENV antibodies to ZIKV. Thus, major caveats must be exercised in using existing diagnostic tools for ZIKV. © 2016 Hainan Medical University
Keyword
Dengue virus | phylogenetic analysis | protein structure | Southeast Asia | Zika virus
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
Office of the Higher Education Commission; Mahidol University
License
CC BY-NC-SA
Rights
Wolters Kluwer Medknow Publications
Publication Source
Scopus