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In vitro and cellular activities of the selected fruits residues for skin aging treatment
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Metadata
Document Title
In vitro and cellular activities of the selected fruits residues for skin aging treatment
Author
Lourith N., Kanlayavattanakul M., Chaikul P., Chansriniyom C., Bunwatcharaphansakun P.
Name from Authors Collection
Scopus Author ID
57194431058
Affiliations
School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai, 57100, Thailand; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand; National Nanotechnology Center, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand
Type
Article
Source Title
Anais da Academia Brasileira de Ciencias
ISSN
00013765
Year
2017
Volume
89
Issue
1
Page
577-589
Open Access
Gold, Green
Publisher
Academia Brasileira de Ciencias
DOI
10.1590/0001-3765201720160849
Abstract
Peel extracts of litchi and rambutan, and that of tamarind seed coat were investigated in relation to their utility in skin-aging treatments. Standardized extracts of tamarind were significantly (p < 0.05) more efficient at O2•- scavenging (IC50 = 27.44 ± 0.09) than those of litchi and rambutan (IC50 = 29.57 ± 0.30 and 39.49 ± 0.52 μg/ml, respectively) and the quercetin standard (IC50 = 31.88 ± 0.15 μg/ml). Litchi extract proved significantly (p < 0.05) more effective for elastase and collagenase inhibition (88.29 ± 0.25% and 79.46 ± 0.92%, respectively) than tamarind (35.43 ± 0.68% and 57.69 ± 5.97%) or rambutan (31.08 ± 0.38% and 53.99 ± 6.18%). All extracts were safe to human skin fibroblasts and inhibit MMP-2, with litchi extract showing significantly (p < 0.01) enhanced inhibition over the standard, vitamin C (23.75 ± 2.74% and 10.42 ± 5.91% at 0.05 mg/ml, respectively). Extracts suppress melanin production in B16F10 melanoma cells through inhibition of tyrosinase and TRP-2, with litchi extract being the most potent, even more so than kojic acid (standard). These results highlight the potential for adding value to agro-industrial waste, as the basis for the sustainable production of innovative, safe, anti-aging cosmetic products. © 2017, Academia Brasileira de Ciencias. All rights reserved.
Keyword
Agro-industrial waste | Antioxidant | Cellular activities | Cosmetics | Enzyme inhibitions | Fruit crop
Funding Sponsor
National Research Council of Thailand
License
CC BY
Rights
Author
Publication Source
Scopus