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Development of chrysin loaded oil-in-water nanoemulsion for improving bioaccessibility
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Metadata
Document Title
Development of chrysin loaded oil-in-water nanoemulsion for improving bioaccessibility
Author
Ting P., Srinuanchai W., Suttisansanee U., Tuntipopipat S., Charoenkiatkul S., Praengam K., Chantong B., Temviriyanukul P., Nuchuchua O.
Name from Authors Collection
Affiliations
Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok, 10400, Thailand; Nano Agricultural Chemistry and Processing Research Team, National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Klong Luang, Pathum Thani, 12120, Thailand; Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom, 73170, Thailand; Department of Pre-Clinical and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand
Type
Article
Source Title
Foods
ISSN
23048158
Year
2021
Volume
10
Issue
8
Open Access
Gold, Green
Publisher
MDPI AG
DOI
10.3390/foods10081912
Abstract
Chrysin (5,7-dihydroxyflavone) is a remarkable flavonoid exhibiting many health-promoting activities, such as antioxidant, anti-inflammatory, and anti-Alzheimer’s disease (AD). Nevertheless, chrysin has been addressed regarding its limited applications, due to low bioaccessibility. There-fore, to improve chrysin bioaccessibility, a colloidal delivery system involving nanoemulsion was developed as chrysin nanoemulsion (chrysin-NE) using an oil-in-water system. Our results show that chrysin can be loaded by approximately 174.21 µg/g nanoemulsion (100.29 ± 0.53% w/w) when medium chain triglyceride (MCT) oil was used as an oil phase. The nanocolloidal size, polydispersity index, and surface charge of chrysin-NE were approximately 161 nm, 0.21, and −32 mV, respectively. These properties were stable for at least five weeks at room temperature. Furthermore, in vitro chrysin bioactivities regarding antioxidant and anti-AD were maintained as pure chrysin, suggest-ing that multistep formulation could not affect chrysin properties. Interestingly, the developed chrysin-NE was more tolerant of gastrointestinal digestion and significantly absorbed by the human intestinal cells (Caco-2) than pure chrysin. These findings demonstrate that the encapsulation of chrysin using oil-in-water nanoemulsion could enhance the bioaccessibility of chrysin, which might be subsequently applied to food and nutraceutical industries. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keyword
Bioaccessibility | Chrysin | Encapsulation | Flavonoid | Nanoemulsion
Funding Sponsor
National Science and Technology Development Agency; Thailand Graduate Institute of Science and Technology
License
CC BY
Rights
Author
Publication Source
Scopus