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Ascochlorin derivatives from the leafhopper pathogenic fungus Microcera sp BCC 17074
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Document Title
Ascochlorin derivatives from the leafhopper pathogenic fungus Microcera sp BCC 17074
Author
Isaka M, Yangchum A, Supothina S, Laksanacharoen P, Luangsa-ard JJ, Hywel-Jones NL
Name from Authors Collection
Affiliations
National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC)
Type
Article
Source Title
JOURNAL OF ANTIBIOTICS
ISSN
0021-8820
Year
2015
Volume
68
Open Access
Bronze
Publisher
NATURE PUBLISHING GROUP
DOI
10.1038/ja.2014.90
Format
Abstract
Two new ascochlorin derivatives, nectchlorins A (1) and B (2), together with eight known compounds (3-10), were isolated from cultures of the leafhopper pathogen Microcera sp. BCC 17074. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of 2 was determined by application of the modified Mosher's method. The absolute configuration of LL-Z 1272 alpha epoxide (9), which is a plausible biosynthetic precursor of ascochlorins, was established by chemical correlations. Cytotoxic activities of these ascochlorin derivatives were evaluated.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
National Center for Genetic Engineering and Biotechnology (BIOTEC)
License
Copyright
Rights
Japan Antibiotics Research Association
Publication Source
WOS