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Structural and Electrochemical Analysis of Copper-Creatinine Complexes: Application in Creatinine Detection
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Document Title
Structural and Electrochemical Analysis of Copper-Creatinine Complexes: Application in Creatinine Detection
Author
Ngamchuea K, Wannapaiboon S, Nongkhunsan P, Hirunsit P, Fongkaew I
Name from Authors Collection
Affiliations
Suranaree University of Technology; Suranaree University of Technology; Suranaree University of Technology; National Science & Technology Development Agency - Thailand; National Nanotechnology Center (NANOTEC)
Type
Article
Source Title
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
ISSN
0013-4651
Year
2022
Volume
169
Issue
2
Page
-
Open Access
hybrid
Publisher
ELECTROCHEMICAL SOC INC
DOI
10.1149/1945-7111/ac5346
Format
Abstract
The formation of complexes between copper ions and biomolecules plays important roles in biological systems. In this work, the structures and electrochemical properties of copper-creatinine complexes were investigated by both experimental and computational approaches. DFT calculation revealed the possible structures of copper-creatinine complexes and provided the data of formation energies, bond lengths, and charge distribution. The properties of the complexes were further investigated by cyclic voltammetry, UV-visible spectrophotometry, X-ray absorption spectroscopy, and scanning electron microscopy. The combination of experimental and computational findings revealed that Cu-II binds with creatinine via the endocyclic nitrogen. In aqueous environment, the [Cu(creatinine)(2)(H2O)(2)](2+) complex is formed. The reduction of [Cu(creatinine)(2)(H2O)(2)](2+) formed a stable 1:4 complex between Cu-I and creatinine. Importantly, the understanding of the electrochemical behaviors of copper-creatinine complexes leads to the development of a novel sensor for the detection of creatinine, a biomarker for kidney diseases. Although creatinine itself is not electroactive, the complex formation with copper allows the species to be detected electrochemically with the sensitivity of 6.09 +/- 0.13 mu A mM(-1) and the limit of detection (3s(B)/m) of 35 mu M.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Funding Sponsor
Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand [Research Grant for New Scholar (RGNS)] [RGNS 63-118]; Royal Society of Chemistry's Research Fund [RF19-5908]; Research Network NANOTEC (RNN) program of the National Nanotechnology Center (NANOTEC), NSTDA, Ministry of Higher Education, Science, Research and Innovation (MHESI), Thailand
License
CC BY-NC-ND
Rights
Authors
Publication Source
WOS