University of North Carolina; University of North Carolina Chapel Hill; Texas A&M University System; Texas A&M University College Station; National Science & Technology Development Agency - Thailand; National Nanotechnology Center (NANOTEC)
Type
Article
Source Title
RSC ADVANCES
ISSN
2046-2069
Year
2017
Volume
7
Issue
29
Page
17748-17751
Open Access
gold, Green Published
Publisher
ROYAL SOC CHEMISTRY
DOI
10.1039/c6ra28806e
Format
PDF
Abstract
N-Heterocyclic carbene boron trifluoride (NHC-BF3) conjugates were successfully radiofluorinated by SnCl4-promoted F-18-F-19 isotopic exchange reaction in one labelling step. This method afforded in vivo stable PET agents that efficiently bound to targeted tumours yielding PET images with good tumour-to-background contrast.
Funding Sponsor
National Cancer Institute [P30-CA016086-35-37]; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill
