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2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae)
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Metadata
Document Title
2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae)
Author
Auranwiwat C, Wongsomboon P, Thaima T, Rattanajak R, Kamchonwongpaisan S, Willis AC, Lie W, Pyne SG, Limtharakul T
Name from Authors Collection
Affiliations
Chiang Mai University; Chiang Mai University; University of Wollongong; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC); Australian National University
Type
Article
Source Title
FITOTERAPIA
ISSN
0367-326X
Year
2017
Volume
120
Page
103-107
Open Access
Green Submitted
Publisher
ELSEVIER SCIENCE BV
DOI
10.1016/j.fitote.2017.06.002
Format
Abstract
Three new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A-C (1-3), and a new polyoxygenated cyclohexene derivative, (-)-uvaribonol F (4) together with six known compounds, 5-10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all isolated compounds were elucidated by spectroscopic analysis. The structures of 3 and 4 were further confirmed by single crystal X-ray diffraction methods. Compound 2 exhibited modest antiplasmodial activity against the P. falcipartun stains TM4/8.2 and K1CB1 with IC50 values of 18.8 +/- 3.63 and 23.4 +/- 4.08 pM, respectively, and weak cytotoxicity to a Vero cell line. Furthermore, compound 4 displayed cytotoxic activity against a KB cell line with an IC50 value of 22.1 +/- 0.42 pM but was non-cytotoxic to the Vero cell line. Compound 5 revealed stronger cytotoxicity towards the KB cell line, with an IC50 value of 5.05 +/- 0.86 mu M and was nearly equally cytotoxic to the Vero cell line.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Funding Sponsor
CMU; Science Achievement Scholarship of Thailand (SAST); Development and Promotion for Science and Technology talents project (ASDPST); Vero cells; NSTDA's Cluster Program Management; Graduate School
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Copyright
Rights
Publisher
Publication Source
WOS