-
Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
- Back
Metadata
Document Title
Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
Author
Ramli RA, Pudjiastuti P, Tjahjandaric TS, Lie W, Rattanajak R, Kamchonwongpaisan S, Pyne SG
Name from Authors Collection
Affiliations
University of Wollongong; Universiti Sains Islam Malaysia; Airlangga University; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC)
Type
Article
Source Title
PHYTOCHEMISTRY LETTERS
Year
2015
Volume
11
Page
157-162
Open Access
Green Accepted, Green Submitted
Publisher
ELSEVIER SCIENCE BV
DOI
10.1016/j.phytol.2014.12.009
Format
Abstract
Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S*), 12(R*)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 +/- 3.7, 16.8 +/- 5.4, 16.0 +/- 4.2 mg/mL, respectively) and K1 (IC50 values of 16.8 +/- 3.1, 14.1 +/- 3.7, 11.9 +/- 3.3 mu g/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
Ministry of Higher Education of Malaysia; Islamic and Science University of Malaysia; University of Wollongong
License
Copyright
Rights
Publisher
Publication Source
WOS