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alpha-Pyrone and decalin derivatives from the marine-derived fungus Trichoderma harzianum PSU-MF79
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Document Title
alpha-Pyrone and decalin derivatives from the marine-derived fungus Trichoderma harzianum PSU-MF79
Author
Nuansri S, Rukachaisirikul V, Rungwirain N, Kaewin S, Yimnual C, Phongpaichit S, Preedanon S, Sakayaroj J, Muanprasat C
Name from Authors Collection
Affiliations
Prince of Songkla University; Prince of Songkla University; Mahidol University; Prince of Songkla University; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC); Walailak University
Type
Article
Source Title
NATURAL PRODUCT RESEARCH
Year
2022
Volume
36
Issue
21
Page
5462-5469
Open Access
Green Submitted
Publisher
TAYLOR & FRANCIS LTD
DOI
10.1080/14786419.2021.2015593
Format
Abstract
Two new compounds, one alpha-pyrone (trichoharzianone) and one decalin (trichoharzianin), along with eight known compounds including three decalins, two delta-lactones, two carboxylic acids and one isochroman were isolated from the marine-derived fungus Trichoderma harzianum PSU-MF79. The structures were determined by spectroscopic methods. The relative configuration of trichoharzianin was assigned based on NOEDIFF data and coupling constants whereas the absolute configurations were established by comparison of electronic circular dichroism data with those of the co-metabolites. Known (-)-massoia lactone exhibited mild antifungal activity against Cryptococcus neoformans ATCC90113 flucytosine-resistant, Candida albicans ATCC90028 and C. albicans NCPF3153 with MIC values of 128, 200 and 200 mu g/mL, respectively, and weak cytotoxic activity against HCT-116 and MCF-7 cell lines with the respective IC50 values of 17 and 32 mu M. In addition, it was noncytotoxic against noncancerous Vero cells with an IC50 value of >100 mu M.
Funding Sponsor
NSTDA Chair Professor grant (Fourth Grant) of the Crown Property Bureau; Thailand Science Research and Innovation [DBG6180029]; National Research Council of Thailand; Faculty of Science, Prince of Songkla University; Graduate School, Prince of Songkla University
Publication Source
WOS