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Antimicrobial substances from the rare actinomycete Nonomuraea rhodomycinica NR4-ASC07(T)
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Document Title
Antimicrobial substances from the rare actinomycete Nonomuraea rhodomycinica NR4-ASC07(T)
Author
Supong K, Sripreechasak P, Phongsopitanun W, Tanasupawat S, Danwisetkanjana K, Bunbamrung N, Pittayakhajonwut P
Name from Authors Collection
Scopus Author ID
56300676200
Scopus Author ID
7801594916
Affiliations
Rajamangala University of Technology Tawan-ok; Chulalongkorn University; Burapha University; Ramkhamhaeng University; National Science & Technology Development Agency - Thailand
Type
Article
Source Title
NATURAL PRODUCT RESEARCH
Year
2019
Volume
33
Issue
16
Page
2285-2291
Open Access
Green Submitted
Publisher
TAYLOR & FRANCIS LTD
DOI
10.1080/14786419.2018.1440223
Format
Abstract
Nonomuraea rhodomycinica NR4-ASC07(T) is a rare actinomycete isolated from soil in Sirindhorn peat swamp forest. The crude extract of its culture broth exhibited antimicrobial and anticancer against diverse human pathogens and cancer cells. The chemical investigation of the crude extract led to the isolation of two new metabolites named nonomuric acid (1) and 3-hydroxy deoxydaunorubicinol aglycone (2), along with two known bioactive compounds [epsilon-rhodomycinone (3) and 7-deoxy-13-dihydrocarminomycinone (4)]. Compounds 1 and 3 showed antimalarial activity with the half maximal inhibitory concentration (IC50) of 8.00 and 8.88 mu g mL(-1), respectively. Compound 4 inhibited growth of Mycobacterium tuberculosis and Bacillus cereus at the minimum inhibitory concentrations of 50.0 and 12.50 mu g mL(-1), respectively. Every compound exhibited cytotoxicity against cancer cells tested at IC50 >= 6.34 mu g mL(-1). These finding are the first report of bioactive metabolites produced by strain NR4-ASC07(T), suggesting that rare actinomycetes are yet promising sources for novel drug discovery. [GRAPHICS] .
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
National Center for Genetic Engineering and Biotechnology [P16-51093]; Rachadapiseksompote Endowment Fund from Chulalongkorn University [GCURP_58_01_33_01]
License
Copyright
Rights
Informa UK Limited, trading as Taylor & Francis Group
Publication Source
WOS