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GC-MS and Bioassay-Guided Isolation of Xanthones from Mammea siamensis
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Document Title
GC-MS and Bioassay-Guided Isolation of Xanthones from Mammea siamensis
Author
Kumutanat W., Hongthong S., Thanasansurapong S., Kongkum N., Chumnanvej N.
Affiliations
Division of Chemistry and Multidisciplinary Research in Chemistry (MulRiC) Laboratory, Faculty of Science and Technology, Rajabhat Rajanagarindra University, Chachoengsao24000, Thailand; Center of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand; National Nanotechnology Center, NSTDA, 111 Thailand Science Park, Klong Luang, Pathum Thani12120, Thailand; Division of Chemistry, Faculty of Science and Technology, Surindra Rajabhat University, Surin, 32000, Thailand; Department of Fundamental Science and Physical Education, Faculty of Science at Sriracha, Kasetsart University, Chonburi20230, Thailand
Type
Article
Source Title
Indonesian Journal of Chemistry
ISSN
14119420
Year
2023
Volume
23
Issue
3
Page
716-726
Open Access
All Open Access, Gold
Publisher
Gadjah Mada University
DOI
10.22146/ijc.79987
Format
Abstract
Mammea siamensis (Miq.) T. Anders. (Calophyllaceae) plants have long been employed as an active integral composition in Thai traditional medicine. Additionally, phenylcoumarins and triterpenes were reported as major components in phytochemical research. This work explored the various parts of M. siamensis; barks, flowers, twigs, leaves, and young leaves; to determine their bioactive compounds. By using the GC-MS and bioassay guidance, two xanthones, 6-deoxyisojacareubin (1) and 1,5-dihydroxyxanthone (2), together with a mixture of phenylcoumarins, mammea A/AA cyclo D (3) and mammea A/AB cyclo D (4) have been isolated from the methanolic extract of young leaves. Their structures were identified by means of spectroscopic technique and by comparison with literature data. In particular, the current study was the first exposed report of xanthones 1 and 2 from the genus Mammea. Furthermore, compounds 1 and 2 and the methanolic young leaf extract had high antioxidant efficiency on DPPH and ABTS assays. The young leaf extract provided mild toxicity on the brine shrimp lethality test (BSLT) with LC50 value of 93.11 ? 1.37 ?g/mL. In addition, the isolated compounds 1 and 2 were non-toxicity in BSLT assay. Therefore, the young leaf extract and the purified constituents 1 and 2 should be further studied and developed for using in pharmaceutical industries. ? 2023, Gadjah Mada University. All rights reserved.
Keyword
antioxidant activity | Mammea siamensis | phenylcoumarins | Toxicity | xanthones
License
CC BY-NC-ND
Rights
Authors
Publication Source
WOS