• CFD Investigation into Influences of a Transversely and Periodically Deforming Microchannel on Shear Stress Behavior in a Gut-on-a-chip Device

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Document Title

CFD Investigation into Influences of a Transversely and Periodically Deforming Microchannel on Shear Stress Behavior in a Gut-on-a-chip Device

Author

Borwornpiyawat P. Juntasaro E. Aueviriyavit S. Juntasaro V. Sripumkhai W. Pattamang P. Meananeatra R. Kulthong K. Wongwanakul R. Khemthongcharoen N. Bumphenkiattikul P. Vongachariya A. Atthi N. Jeamsaksiri W.

Affiliations

Mechanical Engineering Simulation and Design Group The Sirindhorn International Thai-German Graduate School of Engineering (TGGS) King Mongkut抯 University of Technology North Bangkok (KMUTNB) Bangkok 10800 Thailand; Nano Safety and Bioactivity Research Team National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA) Pathum Thani 12120 Thailand; Department of Mechanical Engineering Kasetsart University Bangkok 10900 Thailand; Thai Microelectronics Center (TMEC) National Electronics and Computer Technology Center (NECTEC) National Science and Technology Development Agency (NSTDA) Chacheongsao 24000 Thailand; National Electronics and Computer Technology Center (NECTEC) National Science and Technology Development Agency (NSTDA) Pathum Thani 12120 Thailand; Simulation Technology Digital Manufacturing SCG Chemicals Public Company Limited Bangkok 10800 Thailand

Type

Article

Source Title

Engineering Journal

ISSN

1258281

Year

2023

Volume

27

Issue

5

Page

51-67

Open Access

All Open Access Bronze Green

Publisher

Chulalongkorn University Faculty of Fine and Applied Arts

DOI

10.4186/ej.2023.27.5.51

Abstract

Organ-on-a-chip allows dynamic microenvironment of the actual organ to be simulated in vitro. In this study the CFD simulation is used to investigate the behaviors of fluid flow and shear stress due to the effect of a transversely deforming membrane caused by the cyclic deformation of the microchannel sidewalls in a gut-on-a-chip device. The result reveals that the shear stress varies linearly along the length of the microchannel. The average shear stress per cycle is approximately three times greater than that of the stationary microchannel. The amplitude and frequency of the cyclic deformation also significantly affect the flow and shear stress behaviors. The highly dynamic shear stress in the gut-on-a-chip device could be one of the major factors that makes this kind of device more viable than the traditional static cell culture. ? 2023 Chulalongkorn University Faculty of Fine and Applied Arts. All rights reserved.

Industrial Classification

N/A

Knowledge Taxonomy Level 1

Engineering and Technology

Knowledge Taxonomy Level 2

Bioengineering

Knowledge Taxonomy Level 3

Bioengineering

License

CC BY-NC-ND

Rights

Authors

Publication Source

Scopus

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