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Aza-BODIPY-based polymeric nanoparticles for photothermal cancer therapy in a chicken egg tumor model
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Document Title
Aza-BODIPY-based polymeric nanoparticles for photothermal cancer therapy in a chicken egg tumor model
Author
Chansaenpak K. Yong G.Y. Prajit A. Hiranmartsuwan P. Selvapaandian S. Ouengwanarat B. Khrootkaew T. Pinyou P. Kue C.S. Kamkaew A.
Affiliations
National Nanotechnology Center National Science and Technology Development Agency Thailand Science Park Pathum Thani 12120 Thailand; Faculty of Health and Life Sciences Management and Science University Seksyen 13 Selangor Shah Alam 40100 Malaysia; School of Chemistry Institute of Science Suranaree University of Technology Nakhon Ratchasima 30000 Thailand
Type
Article
Source Title
Nanoscale Advances
ISSN
25160230
Year
2023
Volume
6
Issue
2
Page
406-417
Open Access
All Open Access Gold Green
Publisher
Royal Society of Chemistry
DOI
10.1039/d3na00718a
Abstract
A new push-pull aza-BODIPY (AZB-CF3) derivative comprised of dimethylamino groups and trifluoromethyl moieties was successfully synthesized. This derivative exhibited broad absorption in the near-infrared region in the range from 798 to 832 nm. It also exhibited significant near-infrared (NIR) signals in low-polar solvents with emission peaks around 835-940 nm while non-fluorescence in high-polar environments due to the twisted intramolecular charge transfer (TICT) phenomenon. The nanoprecipitation of this compound with phospholipid-based polyethylene glycol (DSPE-PEG) yielded AZB-CF3@DSPE-PEG nanoparticles (NPs) with a hydrodynamic size of 70 nm. The NPs exhibited good photostability colloidal stability biocompatibility and excellent photothermal (PTT) competence with a conversion efficiency (?) of 44.9%. These NPs were evaluated in vitro and in ovo in a 4T1 breast cancer cell line for NIR light-trigger photothermal therapy. Proven in the chicken egg tumor model AZB-CF3@DSPE-PEG NPs induced severe vascular damage (?40% vascular destruction) showed great anticancer efficacy (?75% tumor growth inhibition) and effectively inhibited distant metastasis via photothermal treatment. As such this PTT-based nanocarrier system could be a potential candidate for a clinical cancer therapy approach. ? 2024 RSC.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY-NC
Rights
Authors
Publication Source
Scopus