• Comparative genomics and genome-wide SNPs of endangered Eld抯 deer provide breeder selection for inbreeding avoidance

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Document Title

Comparative genomics and genome-wide SNPs of endangered Eld抯 deer provide breeder selection for inbreeding avoidance

Author

Pumpitakkul V. Chetruengchai W. Srichomthong C. Phokaew C. Pootakham W. Sonthirod C. Nawae W. Tongsima S. Wangkumhang P. Wilantho A. Utara Y. Thongpakdee A. Sanannu S. Maikaew U. Khuntawee S. Changpetch W. Phromwat P. Raschasin K. Sarnkhaeveerakul P. Supapannachart P. Buthasane W. Pukazhenthi B.S. Koepfli K.-P. Suriyaphol P. Tangphatsornruang S. Suriyaphol G. Shotelersuk V.

Affiliations

Biochemistry Unit Department of Physiology Faculty of Veterinary Science Chulalongkorn University Bangkok 10330 Thailand; Center of Excellence for Medical Genomics Medical Genomics Cluster Department of Pediatrics Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand; Excellence Center for Genomics and Precision Medicine King Chulalongkorn Memorial Hospital The Thai Red Cross Society Bangkok 10330 Thailand; National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency Pathum Thani 12120 Thailand; Zoological Park Organization of Thailand Animal Conservation and Research Institute Bangkok 10800 Thailand; Khao Kheow Open Zoo Zoological Park Organization of Thailand Chonburi 20110 Thailand; Ubon Ratchathani Zoo Zoological Park Organization of Thailand Ubon Ratchathani District Ubon Ratchathani 34000 Thailand; Nakhon Ratchasima Zoo Zoological Park Organization of Thailand Nakhon Ratchasima 30000 Thailand; Huai Kha Khaeng Wildlife Breeding Center Department of National Parks Wildlife and Plant Conservation Uthai Thani 61160 Thailand; Chulabhorn Wildlife Breeding Center Department of National Parks Wildlife and Plant Conservation Sisaket 33140 Thailand; Banglamung Wildlife Breeding Center Department of National Parks Wildlife and Plant Conservation Chonburi 20150 Thailand; Center for Species Survival Smithsonian Conservation Biology Institute National Zoological Park Front Royal VA 22630 United States; Smithsonian-Mason School of Conservation George Mason University Front Royal VA 22630 United States; Office for Research and Development Faculty of Medicine Siriraj Hospital Mahidol University Bangkok 10700 Thailand

Type

Article

Source Title

Scientific Reports

ISSN

20452322

Year

2023

Volume

13

Issue

1

Open Access

All Open Access Gold Green

Publisher

Nature Research

DOI

10.1038/s41598-023-47014-x

Abstract

Eld抯 deer a conserved wildlife species of Thailand is facing inbreeding depression particularly in the captive Siamese Eld抯 deer (SED) subspecies. In this study we constructed genomes of a male SED and a male Burmese Eld抯 deer (BED) and used genome-wide single nucleotide polymorphisms to evaluate the genetic purity and the inbreeding status of 35 SED and 49 BED with limited pedigree information. The results show that these subspecies diverged approximately 1.26 million years ago. All SED were found to be purebred. A low proportion of admixed SED genetic material was observed in some BED individuals. Six potential breeders from male SED with no genetic relation to any female SED and three purebred male BED with no relation to more than 10 purebred female BED were identified. This study provides valuable insights about Eld抯 deer populations and appropriate breeder selection in efforts to repopulate this endangered species while avoiding inbreeding. ? 2023 The Author(s).

License

CC BY

Rights

Authors

Publication Source

WOS

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