• A 2D-proteomic analysis identifies proteins differentially regulated by two different dengue virus serotypes

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Document Title

A 2D-proteomic analysis identifies proteins differentially regulated by two different dengue virus serotypes

Author

Chumchanchira C., Ramphan S., Paemanee A., Roytrakul S., Lithanatudom P., Smith D.R.

Affiliations

Graduate Program in Environmental and Water Resources Engineering, Department of Civil and Environmental Engineering, Faculty of Engineering, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom, 73170, Thailand; Nanocomposite Engineering Laboratory (NanoCEN), Department of Chemical Engineering, Faculty of Engineering, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom, 73170, Thailand; Faculty of Environment and Resource Studies, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom, 73170, Thailand; Department of Civil Engineering, Faculty of Engineering, Thammasat University, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand; National Metal and Materials Technology Center, National Science and Technology Development Agency, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand; Graduate School of Global Environmental Studies, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501, Japan

Type

Article

Source Title

ACS Omega

ISSN

24701343

Year

2024

Volume

9

Issue

22

Page

23172-23183

Open Access

All Open Access, Gold

Publisher

American Chemical Society

DOI

10.1021/acsomega.3c06705

Abstract

The harmful effects of antibiotic proliferation on the environment and its persistent nature are urgent global problems. Ciprofloxacin (CIP) is a fluoroquinolone-class antibiotic agent used widely to treat pathogen-related diseases in humans and animals. Its excretion into surface water causes antibiotic resistance in microbes, resulting in difficult-to-treat or untreatable infectious diseases. This study developed a simple and efficient electrochemical sensor to detect CIP. Hydrothermal chemistry was utilized to synthesize an electrophotocatalytic composite of copper-iron mixed metal oxides (CIMMO) on reduced graphene oxide (rGO) (CIMMO/rGO). The composite was employed in an electrochemical sensor and exhibited outstanding performance in detecting CIP. The sensor was operated in differential pulse voltammetry (DPV) mode under light source illumination. The sensor yielded a linear response in the concentration range of 0.75 ? 10-9-1.0 ? 10-7 mol L-1 CIP and showed a limit of detection (LOD) of 4.74 ? 10-10 mol L-1. The excellent sensing performance of the composite is attributable to the synergic effects between CIMMO nanoparticles and rGO, which facilitate photoinduced electron-hole separation and assist in the indirect electrochemical reactions/interactions with CIP. ? 2024 The Authors. Published by American Chemical Society.

License

CC BY

Rights

Authors

Publication Source

WoS

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