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Synthesis, structural characterization, computational studies and stability evaluations of metal ions and ZnONPs complexes with dimercaptosuccinic acid
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Document Title
Synthesis, structural characterization, computational studies and stability evaluations of metal ions and ZnONPs complexes with dimercaptosuccinic acid
Author
Keattanong P., Wasukan N., Kuno M., Srisung S.
Name from Authors Collection
Affiliations
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumwit 23, Wattana District, Bangkok, 10110, Thailand; National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Khlong LuangPathum Thani 12120, Thailand
Type
Article
Source Title
Heliyon
ISSN
24058440
Year
2021
Volume
7
Issue
1
Open Access
All Open Access, Gold, Green
Publisher
Elsevier Ltd
DOI
10.1016/j.heliyon.2021.e05962
Format
Abstract
Meso-2,3-dimercaptosuccinic acid (DMSA); Metal complex; Zinc oxide nanoparticles (ZnONPs); Stability constant; Computational chemistry. © 2021 The Author(s)Meso-2,3-dimercaptosuccinic acid (DMSA) is one of the efficient chelating reagents for treating the toxicity of several heavy metals. Currently, nanomaterial have been applied to various parts including zinc Oxide nanoparticles (ZnONPs). ZnONPs have several properties and are used as many applications. An increasing the amount of ZnONPs in commercial products causes risks related to free radicals or reactive oxygen species (ROS) in the body, leading to oxidative stress and eventually to the cancer process. In the present work, we mainly focused on the study of DMSA complexes in term of metal ions and nanoparticles. The synthesis of DMSA-ZnONPs by the co-precipitation method were determined, followed by Scanning Electron Microscope, Fourier Transform Infrared Spectroscopy and UV-Vis spectrophotometry confirming successful synthesis process. The stability study of the DMSA complexes with metal ions and ZnONPs were determined and evaluated the stability constant (K), with the Benesi- Hildebrand equation. All complexes with DMSA were formed at a 1:2 ratio by the dithiol group and the carboxyl group with different stability constants. Therefore, these results can help of an understanding of the interaction and its behavior between DMSA with heavy metal ion and ZnONPs. In addition, the stable structure of DMSA and metal ion complexes were predicted using the B3LYP and the 6-31G (d,p) basis set which the most stable structure of meso-DMSA was 2R,3S conformation and the metal ions and DMSA complexes was complex 2a with the binding energy of -1553.46 kcal mol−1. © 2021 The Author(s)
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
National Science and Technology Development Agency; Srinakharinwirot University
License
N/A
Rights
N/A
Publication Source
Scopus