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Formation of double emulsion micro-droplets in a microfluidic device using a partially hydrophilic-hydrophobic surface
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Document Title
Formation of double emulsion micro-droplets in a microfluidic device using a partially hydrophilic-hydrophobic surface
Author
Kamnerdsook A., Juntasaro E., Khemthongcharoen N., Chanasakulniyom M., Sripumkhai W., Pattamang P., Promptmas C., Atthi N., Jeamsaksiri W.
Name from Authors Collection
Scopus Author ID
35488706300
Affiliations
Mechanical Engineering Simulation and Design Group, Sirindhorn International Thai-German Graduate School of Engineering (TGGS), King Mongkut's University of Technology North Bangkok, Bangkok, 10800, Thailand; Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, 73170, Thailand; Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, 73170, Thailand; Thai Microelectronics Center (TMEC), National Electronics and Computer Technology Center, National Science and Technology Development Agency, Chachoengsao, 24000, Thailand
Type
Article
Source Title
RSC Advances
ISSN
20462069
Year
2021
Volume
11
Issue
56
Page
35653-35662
Open Access
Gold
Publisher
Royal Society of Chemistry
DOI
10.1039/d1ra06887c
Abstract
The objective of this paper is to propose a surface modification method for preparing PDMS microfluidic devices with partially hydrophilic-hydrophobic surfaces for generating double emulsion droplets. The device is designed to be easy to use without any complicated preparation process and also to achieve high droplet encapsulation efficiency compared to conventional devices. The key component of this preparation process is the permanent chemical coating for which the Pluronic surfactant is added into the bulk PDMS. The addition of Pluronic surfactant can modify the surface property of PDMS from a fully hydrophobic surface to a partially hydrophilic-hydrophobic surface whose property can be either hydrophilic or hydrophobic depending on the air- or water-treatment condition. In order to control the surface wettability, this microfluidic device with the partially hydrophilic-hydrophobic surface undergoes water treatment by injecting deionized water into the specific microchannels where their surface property changes to hydrophilic. This microfluidic device is tested by generating monodisperse water-in-oil-in-water (w/o/w) double emulsion micro-droplets for which the maximum droplet encapsulation efficiency of 92.4% is achieved with the average outer and inner diameters of 75.0 and 57.7 μm, respectively. © 2021 The Royal Society of Chemistry.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
National Science and Technology Development Agency; Thailand Graduate Institute of Science and Technology; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Ministry of Higher Education, Science, Research and Innovation, Thailand
License
CC BY-NC
Rights
Author
Publication Source
Scopus
Note
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