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Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration
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Document Title
Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration
Author
Khongkow M., Yata T., Boonrungsiman S., Ruktanonchai U.R., Graham D., Namdee K.
Name from Authors Collection
Affiliations
National Nanotechnology Centre (NANOTEC), National Science and Technology Development Agency, 111 Thailand Science Park, Paholyothin Rd., Klong Luang, Pathumthani, 12120, Thailand; Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, United Kingdom
Type
Article
Source Title
Scientific Reports
ISSN
20452322
Year
2019
Volume
9
Issue
1
Open Access
All Open Access, Gold, Green
Publisher
Nature Publishing Group
DOI
10.1038/s41598-019-44569-6
Format
Abstract
Gold nanoparticles (AuNPs) have been extensively used as nanomaterials for theranostic applications due to their multifunctional characteristics in therapeutics, imaging, and surface modification. In this study, the unique functionalities of exosome-derived membranes were combined with synthetic AuNPs for targeted delivery to brain cells. Here, we report the surface modification of AuNPs with brain-targeted exosomes derived from genetically engineered mammalian cells by using the mechanical method or extrusion to create these novel nanomaterials. The unique targeting properties of the AuNPs after fabrication with the brain-targeted exosomes was demonstrated by their binding to brain cells under laminar flow conditions as well as their enhanced transport across the blood brain barrier. In a further demonstration of their ability to target brain cells, in vivo bioluminescence imaging revealed that targeted-exosome coated AuNPs accumulated in the mouse brain after intravenous injection. The surface modification of synthetic AuNPs with the brain-targeted exosome demonstrated in this work represents a highly novel and effective strategy to provide efficient brain targeting and shows promise for the future in using modified AuNPs to penetrate the brain. © 2019, The Author(s).
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
Scottish Funding Council; National Science and Technology Development Agency; National Nanotechnology Center
License
CC BY
Rights
Author
Publication Source
Scopus