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A model of modifiedmeta-iodobenzylguanidine conjugated gold nanoparticles for neuroblastoma treatment
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Metadata
Document Title
A model of modifiedmeta-iodobenzylguanidine conjugated gold nanoparticles for neuroblastoma treatment
Author
Saimuang K.,Suttisintong K.,Kaewchangwat N.,Thanayupong E.,Wongngam Y.,Charoenphun P.,Wanotayan R.,Elaissari A.,Hongeng S.,Polpanich D.,Jangpatarapongsa K.
Name from Authors Collection
Scopus Author ID
57197730706
Scopus Author ID
57194773103
Affiliations
Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA)Pathum Thani 12120, Thailand; Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand; Department of Radiological Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand; Univ. Lyon, University Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, Villeurbanne, 69622, France; Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand
Type
Article
Source Title
RSC Advances
ISSN
20462069
Year
2021
Volume
11
Issue
41
Page
25199-25206
Open Access
All Open Access, Gold, Green
Publisher
Royal Society of Chemistry
DOI
10.1039/d1ra04054e
Abstract
Iodine-131meta-iodobenzylguanidine (131I-mIBG) has been utilized as a standard treatment to minimize adverse side effects by targeting therapies to bind to the norepinephrine transporter (NET) expressed on 90% of neuroblastoma cells. However, only a minority of patients who receive131I-mIBG radiotherapy have clinical responses, and these are usually not curative. In this study, novel ligand-conjugated gold nanoparticles (GNPs) based onmIBG were synthesized and evaluated biologically with neuroblastoma cellsin vitro. To induce specific internalization to the tumor cells and utilize it as a model for radioenhancement,127I-modifiedmIBG was successfully synthesized and grafted covalently to the surface of carboxylated PEG-GNPs. 49.28% of the novelmIBG derivative was grafted on carboxylated PEG-GNPs. The particles were stable and not toxic to the normal fibroblast cell line, L929, even at the highest concentration tested (1013NPs per mL) at 24, 48, and 72 h. Moreover, the cellular uptake of the model was decreased significantly in the presence of a NET inhibitor, suggesting that there was specific internalization into neuroblastoma cells line (SH-SY5Y)viathe NET. Therefore, this model provides useful guidance toward the design of gold nanomaterials to enhance the efficiency of131I-mIBG treatment in neuroblastoma patients. However, the investigation of radio-therapeutic efficiency after radioisotope131I substitution will be further conducted in a radiation safety laboratory using an animal model. © The Royal Society of Chemistry 2021.
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License
CC BY-NC
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Publication Source
Scopus