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Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
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Metadata
Document Title
Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
Author
Bhubhanil S.,Talodthaisong C.,Khongkow M.,Namdee K.,Wongchitrat P.,Yingmema W.,Hutchison J.A.,Lapmanee S.,Kulchat S.
Name from Authors Collection
Affiliations
Pre-Clinical Department, Faculty of Medicine, Siam University, Bangkok, 10160, Thailand; Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand; National Nanotechnology Centre (NANOTEC), National Science and Technology Development Agency, Pathumthani, 12120, Thailand; Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakon Pathom, 73170, Thailand; Laboratory Animal Center, Thammasat University, Pathumthani, 12120, Thailand; School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia
Type
Article
Source Title
Scientific Reports
ISSN
20452322
Year
2021
Volume
11
Issue
1
Open Access
All Open Access, Gold, Green
Publisher
Nature Research
DOI
10.1038/s41598-021-01262-x
Abstract
Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations of their wound healing and safety in vivo in animal studies are scarce. Here we demonstrate that a guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional wound healing and antibacterial properties. We show that the curcumin-bound silver nanoparticles themselves exhibit low cytotoxicity and enhance proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts. We then show that the hydrogel-nanoparticle composite promotes wound healing in in vivo studies on rats, accelerating wound closure by > 40% and reducing bacterial counts by 60% compared to commercial antibacterial gels. Histopathology indicates that the hydrogel composite enhances transition from the inflammation to proliferation stage of healing, promoting the formation of fibroblasts and new blood vessels, while target gene expression studies confirm that the accelerated tissue remodeling occurs along the normal pathways. As such these hydrogel composites show great promise as wound dressing materials with high antibacterial capacity. © 2021, The Author(s).
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY
Rights
Publisher
Publication Source
Scopus