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Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile
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Metadata
Document Title
Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile
Author
Wangchuk P.,Pyne S.G.,Keller P.A.,ITaweechotipatr M.,Kamchonwongpaisan S.
Name from Authors Collection
Affiliations
Queensland Tropical Health Alliance Laboratory, Faculty of Medicine, Health and Molecular Sciences, James Cook University, QLD 4878, Australia; School of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia; Manjong Sorig Pharmaceuticals, Ministry of Health, Thimphu, Bhutan; Department of Microbiology, Faculty of Medicine, Srinakharinwirot University, Sukhumvit 23, Bangkok, 10110, Thailand; Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, 12120, Thailand
Type
Article
Source Title
Natural Product Communications
ISSN
1934578X
Year
2014
Volume
9
Issue
7
Open Access
All Open Access, Bronze, Green
Publisher
Natural Product Incorporation
DOI
10.1177/1934578x1400900719
Abstract
With the objective of determining safety and verifying the traditional uses of the Bhutanese medicinal plant, Pleurospermum amabile Craib & W. W. Smith, we investigated its crude extracts and the isolated phytochemicals for their biological activities. Four phenylpropanoids [(E)-isomyristicin (1), (E)-isoapiol (2 ), methyl eugenol (3) and (E)-isoelemicin (4)] and six furanocoumarins [psoralen (5), bergapten (6), isoimperatorin (7), isopimpinellin (8 ), oxypeucedanin hydrate (9) and oxypeucedanin methanolate (10 )] were isolated from this plant. Among the test samples, compound 10 showed weak antibacterial activity against Bacillus subtilis and best antimalarial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). None of the test samples showed cytotoxicity. This study generated scientific data that support the traditional medical uses of the plant.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY-NC
Rights
SAGE Publishing
Publication Source
Scopus