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Activity of andrographolide against chikungunya virus infection
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Document Title
Activity of andrographolide against chikungunya virus infection
Author
Wintachai P.,Kaur P.,Lee R.C.H.,Ramphan S.,Kuadkitkan A.,Wikan N.,Ubol S.,Roytrakul S.,Chu J.J.H.,Smith D.R.
Name from Authors Collection
Affiliations
Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; Center for Emerging and Neglected Infectious Diseases, Mahidol University, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand
Type
Article
Source Title
Scientific Reports
ISSN
20452322
Year
2015
Volume
5
Open Access
All Open Access, Gold, Green
Publisher
Nature Publishing Group
DOI
10.1038/srep14179
Abstract
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that has recently engendered large epidemics around the world. There is no specific antiviral for treatment of patients infected with CHIKV, and development of compounds with significant anti-CHIKV activity that can be further developed to a practical therapy is urgently required. Andrographolide is derived from Andrographis paniculata, a herb traditionally used to treat a number of conditions including infections. This study sought to determine the potential of andrographolide as an inhibitor of CHIKV infection. Andrographolide showed good inhibition of CHIKV infection and reduced virus production by approximately 3log10 with a 50% effective concentration (EC50) of 77 μM without cytotoxicity. Time-of-addition and RNA transfection studies showed that andrographolide affected CHIKV replication and the activity of andrographolide was shown to be cell type independent. This study suggests that andrographolide has the potential to be developed further as an anti-CHIKV therapeutic agent. © 2015, Nature Publishing Group. All rights reserved.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
Office of the Higher Education Commission; Dahlem Research School, Freie Universität Berlin; Mahidol University; Thailand Research Fund; Thailand Graduate Institute of Science and Technology
License
CC BY
Rights
Nature Portfolio
Publication Source
Scopus