-
Annealed zno/al2o3 core-shell nanowire as a platform to capture rna in blood plasma
- Back
Metadata
Document Title
Annealed zno/al2o3 core-shell nanowire as a platform to capture rna in blood plasma
Author
Takahashi H.,Yasui T.,Klamchuen A.,Khemasiri N.,Wuthikhun T.,Paisrisarn P.,Shinjo K.,Kitano Y.,Aoki K.,Natsume A.,Rahong S.,Baba Y.
Name from Authors Collection
Affiliations
Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, 464-8601, Japan; Japan Science and Technology Agency (JST), Saitama, 332-0012, Japan; Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Nagoya, 464-8601, Japan; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand; Division of Cancer Biology, Graduate School of Medicine, Nagoya University, Nagoya, 466-8560, Japan; Division of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, 466-8560, Japan; King Mongkut’s Institute of Technology Ladkrabang, College of Materials Innovation and Technology, Bangkok, 10520, Thailand; Institute of Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan
Type
Article
Source Title
Nanomaterials
ISSN
20794991
Year
2021
Volume
11
Issue
7
Open Access
All Open Access, Gold, Green
Publisher
MDPI AG
DOI
10.3390/nano11071768
Abstract
RNA analytical platforms gained extensive attention recently for RNA-based molecular analysis. However, the major challenge for analyzing RNAs is their low concentration in blood plasma samples, hindering the use of RNAs for diagnostics. Platforms that can enrich RNAs are essential to enhance molecular detection. Here, we developed the annealed ZnO/Al2O3 core-shell nanowire device as a platform to capture RNAs. We showed that the annealed ZnO/Al2O3 core-shell nanowire could capture RNAs with high efficiency compared to that of other circulating nucleic acids, including genomic DNA (gDNA) and cell-free DNA (cfDNA). Moreover, the nanowire was considered to be biocompatible with blood plasma samples due to the crystalline structure of the Al2O3 shell which serves as a protective layer to prevent nanowire degradation. Our developed device has the potential to be a platform for RNA-based extraction and detection. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY
Rights
Author
Publication Source
Scopus