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Anti-aging of phenolic-rich Acanthus ebracteatus Vahl. extracts
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Document Title
Anti-aging of phenolic-rich Acanthus ebracteatus Vahl. extracts
Author
Kanlayavattanakul M., Chaikul P., Kongkow M., Iempridee T., Lourith N.
Affiliations
School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai, 57100, Thailand; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Pathum Thani, 12120, Thailand
Type
Article
Source Title
Chemical and Biological Technologies in Agriculture
ISSN
21965641
Year
2023
Volume
10
Issue
1
Page
-
Open Access
All Open Access, Gold
Publisher
Springer Science and Business Media Deutschland GmbH
DOI
10.1186/s40538-023-00403-w
Format
Abstract
Background: Sea holly has long been used in traditional Thai medicine for longevity, skin inflammation, skin dullness and as a treatment for itchy skin. The white flower cultivar Acanthus ebracteatus Vahl. has been documented to perform better remedies than the purple flower A. ilicifolius. Nonetheless, preparation of the phenolic-rich extract of A. ebracteatus, including safety and cellular assessments relevant for inflammation and aging treatment is sparingly presented. In this study, the extracts of A. ebracteatus were prepared and comparatively quantified on total phenolic contents. In vitro activities by means of ABTS, DPPH, FRAP and mushroom tyrosinase inhibitory assays were undertaken. The extracts were UPLC analyzed and examined on cellular safety and activities. Results: The phenolic-rich extracts of A. ebracteatus were prepared and standardized in verbascoside. The extracts were noted to have in vitro antioxidant and anti-tyrosinase activities. Cellular activities, co-cultures and ex vivo human skin appointed for cutaneous aging treatment, i.e., photoaging, are promising including antioxidant, anti-melanogenesis, anti-inflammatory (IL-6 and IL-8), anti-MMP and collagen production stimulating as well as anti-senescence activities. Conclusions: Sea holly is highlighted as a potential source for beneficial cutaneous phenolics, especially verbascoside. The extracts were proven to be safe and efficient for cutaneous aging treatment indicated by their antioxidant, anti-melanogenesis, collagen stimulating, anti-inflame and anti-senescence activities. The plant extracts are therefore appointed for use as innovative agents for anti-aging purposes. Graphical Abstract: [Figure not available: see fulltext.]. © 2023, The Author(s).
Funding Sponsor
Mae Fah Luang University; Thailand Science Research and Innovation
Publication Source
WOS