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Antioxidant Activity of Crocodile Oil (Crocodylus爏iamensis) on Cognitive Function in Rats
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Document Title
Antioxidant Activity of Crocodile Oil (Crocodylus爏iamensis) on Cognitive Function in Rats
Author
Srisuksai K. Parunyakul K. Santativongchai P. Phaonakrop N. Roytrakul S. Tulayakul P. Fungfuang W.
Affiliations
Department of Zoology Faculty of Science Kasetsart University Bangkok 10900 Thailand; Bio梀eterinary Science (International Program) Faculty of Veterinary Medicine Kasetsart University Bangkok 10900 Thailand; Functional Ingredient and Food Innovation Research Group National Center for Genetic Engineering and Biotechnology (BIOTEC) National Science and Technology Development Agency Pathum Thani12120 Thailand; Department of Veterinary Public Health Faculty of Veterinary Medicine Kasetsart University Bangkok 10900 Thailand; Rresearch and Development Institute Kasetsart University Bangkok 10900 Thailand
Type
Article
Source Title
Foods
ISSN
23048158
Year
2023
Volume
12
Issue
4
Open Access
All Open Access Gold Green
Publisher
MDPI
DOI
10.3390/foods12040791
Abstract
Crocodile oil (CO) is rich in monounsaturated fatty acids and polyunsaturated fatty acids. The antioxidant activity and cognitive effect of monounsaturated fatty acids and polyunsaturated fatty acids have been largely reported. This work aimed to investigate the effect of CO on antioxidant activity and cognitive function in rats. Twenty-one rats were divided into three treatment groups: (1) sterile water (NS) (2) 1 mL/kg of CO (NC1) and (3) 3 mL/kg of CO (NC3). Rats underwent oral gavage once daily for 8 weeks. CO treatment decreased the triglycerides level significantly compared with that in the NS group. CO had a free radical scavenging ability greater than that of olive oil but had no effect on levels of antioxidant markers in the brain. Expression of unique proteins in the CO-treatment group were correlated with the detoxification of hydrogen peroxide. Rats in the NC1 group had better memory function than rats in the NC3 group. Expression of unique proteins in the NC1 group was correlated with memory function. However CO did not cause a decline in cognitive function in rats. CO can be an alternative dietary oil because it has a hypolipidemia effect and antioxidant activity. In addition CO did not cause a negative effect on cognitive function. ? 2023 by the authors.
Keyword
Antioxidant | Cognitive function | Crocodile oil | hyperlipidemia | Rat
License
CC BY
Rights
Authors
Publication Source
WOS