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Bireticulol, a bioactive isocoumarin dimer from Streptomyces sp BCC24731
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Document Title
Bireticulol, a bioactive isocoumarin dimer from Streptomyces sp BCC24731
Author
Boonlarppradab C, Suriyachadkun C, Suphothina S, Tobwor P
Name from Authors Collection
Affiliations
National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC)
Type
Article
Source Title
JOURNAL OF ANTIBIOTICS
ISSN
0021-8820
Year
2011
Volume
64
Issue
91
Open Access
Bronze
Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI
10.1038/ja.2010.171
Format
Abstract
A new dimeric isocoumarin, bireticulol, was isolated from the terrestrial Streptomyces sp. and characterized as a 5-5' dimer of reticulol. In addition, reticulol and 8-hydroxy-6,7-dimethoxy-3-methyl isocoumarin, together with other known polyketides piericidin A, 2'-(2-hydroxyphenyl)-2,4'-bibenzoxazole-4-carboxylic acid methyl ester (UK-1) and 3-benzyl-4-hydroxy-5-methyldihydrofuran-2-one were also obtained. Bireticulol exhibited cytotoxic effects against KB (human epidermoid carcinoma, ATCC CCL-17) and NCI-H187 (human small cell lung cancer, ATCC CRL-5804) cell lines with IC50 values of 24.4 and 8.31 mu g ml(-1), respectively. The Journal of Antibiotics (2011) 64, 267-270; doi:10.1038/ja.2010.171; published online 12 January 2011
Funding Sponsor
Bioresources Research Network (BRN) of the National Center for Genetic Engineering and Biotechnology (BIOTEC)
License
Copyright
Rights
Japan Antibiotics Research Association
Publication Source
WOS