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Body mass index and its effects on liver fat content in overweight and obese young adults by proton magnetic resonance spectroscopy technique
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Document Title
Body mass index and its effects on liver fat content in overweight and obese young adults by proton magnetic resonance spectroscopy technique
Author
Pasanta D., Tungjai M., Chancharunee S., Sajomsang W., Kothan S.
Name from Authors Collection
Affiliations
Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand; National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, Thailand
Type
Article
Source Title
World Journal of Hepatology
ISSN
19485182
Year
2018
Volume
10
Issue
12
Page
924-933
Open Access
All Open Access, Gold, Green
Publisher
Baishideng Publishing Group Co
DOI
10.4254/wjh.v10.i12.924
Format
Abstract
AIM To assess the association between liver fat content (LFC) and weight status in young adults using proton magnetic resonance spectroscopy (1H MRS) technique. METHODS Seventy-eight healthy young adults, between 19-30 years of age participated in this study. This group was then separated into a control of 39 subjects and an overweight/obese group (OW/OB group) consisting of 39 subjects. Blood biochemical quantity and 1H MRS was performed for LFC assessment. RESULTS LFC was found to be almost three times higher in OW/OB group when compared to the control group. A 48.7% incidence of non-alcoholic fatty liver disease in the OW/OB group was found. Blood biochemical measurements showed statistically higher low-density lipoproteins and triglyceride, lower highdensity lipoproteins, and increased glycosylated hemoglobin and fasting glucose in the OW/OB group. Body mass index was a significant independent predictor for LFC after adjusting for age and sex (multiple linear regression; β = 0.459, P < 0.001). CONCLUSION Due to the prevalence of high LFC in the OW/OB group, it can be proposed that weight gain and obesity are sensitive indicators of high hepatic fat content. © The Author(s) 2018.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY-NC
Rights
Author
Publication Source
Scopus