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Bone regeneration of a polymeric sponge technique-Alloplastic bone substitute materials compared with a commercial synthetic bone material (MBCP+TM technology): A histomorphometric study in porcine skull
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Document Title
Bone regeneration of a polymeric sponge technique-Alloplastic bone substitute materials compared with a commercial synthetic bone material (MBCP+TM technology): A histomorphometric study in porcine skull
Author
Intapibool P, Monmaturapoj N, Nampuksa K, Thongkorn K, Khongkhunthian P
Name from Authors Collection
Scopus Author ID
57221417390
Affiliations
Chiang Mai University; National Science & Technology Development Agency - Thailand; Chiang Mai University
Type
Article
Source Title
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
ISSN
2057-4347
Year
2021
Volume
7
Issue
21
Open Access
Green Published, gold
Publisher
WILEY
DOI
10.1002/cre2.394
Format
Abstract
Background: Polymeric sponge technique is recommended for developing the desired porosity of Biphasic calcium phosphate (BCP) which may favor bone regeneration. Purpose: To investigate the healing of BCP with ratio of HA30/beta-TCP70 (HA30) and HA70/beta-TCP30 (HA70) polymeric sponge preparation, compare to commercial BCP (MBCP+TM). Materials and Methods: Materials were tested X-ray diffraction (XRD) pattern and scanning electron microscope (SEM) analysis. In eight male pigs, six calvarial defects were created in each subject. The defects were the filled with 1 cc of autogenous bone, MBCP+TM (MBCP), HA30, HA70, and left empty (negative group). The new bone formations, residual material particles and bone-to-graft contacts were analyzed at 4, 8, 12 and 16 weeks. Results: Fabricated BCP showed well-distributed porosity. At 16 weeks, new bone formations were 45.26% (autogenous), 33.52% (MBCP), 24.34% (HA30), 19.43% (HA70) and 3.37% (negative). Residual material particles were 1.88% (autogenous), 17.58% (MBCP), 26.74% (HA30) and 37.03% (HA70). These values were not significant differences (Bonferroni correction <0.005). Bone-to-graft contacts were 73.68% (MBCP), which was significantly higher than 41.68% (HA30) and 14.32% (HA70; Bonferroni correction <0.017). Conclusions: Polymeric sponge technique offers well-distributed porosity. The new bone formation and residual material particles were comparable to MBCP+TM, but the bone-to-graft contact was lower than MBCP+TM.
Funding Sponsor
National Metal and Materials Technology Center; NSTDA
License
CC BY
Rights
Authors
Publication Source
WOS