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Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana
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Document Title
Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana
Author
Suksamrarn S., Panseeta P., Kunchanawatta S., Distaporn T., Ruktasing S., Suksamrarn A.
Name from Authors Collection
Affiliations
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Bangkok 10110, Thailand; National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Paholyothin Road, Pathumthani 12120, Thailand; Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
Type
Article
Source Title
Chemical and Pharmaceutical Bulletin
ISSN
00092363
Year
2006
Volume
54
Issue
4
Page
535-537
Open Access
Bronze
DOI
10.1248/cpb.54.535
Abstract
One new and eight known ceanothane- and lupane-type triterpenes were isolated from the root bark of Ziziphus cambodiana PIERRE (Rhamnaceae). Based on spectral analyses, the structure of the new compound was elucidated as 3-O-(4-hydroxy-3-methoxybenzoyl)ceanothic acid (3-O-vanillylceanothic acid) (1), while the known compounds were identified as lupeol (2), betulinaldehyde (3), betulinic acid (4), 2-O-E-p-coumaroyl alphitolic acid (5), alphitolic acid (6), zizyberanalic acid (7), zizyberenalic acid (8) and ceanothic acid (9). Compounds 1, 5 and 8 exhibited significant in vitro antiplasmodial activity against the parasite Plasmodium falciparum, with inhibitory concentration (IC50) values of 3.7, 0.9 and 3.0 μg/ml, respectively. Compounds 1 and 3-8 showed antimycobacterial activity against Mycobacterium tuberculosis with respective MIC values of 25, 25, 25, 12.5, 50, 50 and 100 μg/ml. © 2006 Pharmaceutical Society of Japan.
License
CC BY
Rights
The Pharmaceutical Society of Japan
Publication Source
Scopus