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Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma
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Document Title
Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma
Author
Saesoo S, Sathornsumetee S, Anekwiang P, Treetidnipa C, Thuwajit P, Bunthot S, Maneeprakorn W, Maurizi L, Hofmann H, Rungsardthong RU, Saengkrit N
Name from Authors Collection
Affiliations
National Science & Technology Development Agency - Thailand; National Nanotechnology Center (NANOTEC); Mahidol University; National Science & Technology Development Agency - Thailand; National Nanotechnology Center (NANOTEC); Mahidol University; Mahidol University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Universite de Bourgogne; Universite de Technologie de Belfort-Montbeliard (UTBM); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
Type
Article
Source Title
COLLOIDS AND SURFACES B-BIOINTERFACES
Year
2018
Volume
161
Page
497-507
Open Access
Green Submitted
Publisher
ELSEVIER SCIENCE BV
DOI
10.1016/j.colsurfb.2017.11.003
Format
Abstract
Despite advances in neuroscience cancer research during the past decades, the survival of cancer patients has only marginally improved and the cure remains unlikely. The blood-brain barrier (BBB) is a major obstacle protecting the entry of therapeutic agents to central nervous system, especially for primary central nervous system lymphoma (PCNSL). Thus, the use of small nanoparticle as a drug carrier may be new strategies to overcome this problem. In this study, we fabricated liposome consisting of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with anti-CD20 (Rituximab; RTX). The designed nanoparticles have a theranostic property which is not only to improve drug delivery, but also to offer diagnostic and monitoring capabilities. TEM images revealed the spherical shape of liposome with the approximately average diameters about 140-190 nm with slightly negatively charge surfaces. Super paramagnetic property of SPIONs-loaded liposomes was confirmed by VSM. Liposome colloidal could be prolonged at 4 degrees C and 25 degrees C storages. RTX conjugated liposome induced cell internalization and apoptosis effect in B-lymphoma cells. Drug targeting and therapeutic effect was investigated in BBB model. The result confirmed that liposome nanocarrier is required as a drug carrier for effectively RTX across the BBB. (C) 2017 Elsevier B.V. All rights reserved.
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Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
Faculty of Medicine Siriraj Hospital, Mahidol University; National Nanotechnology Center (NANOTEC), NSTDA, Ministry of Science and Technology, Thailand through its program of Center of Excellence Network; Siriraj Research Faculty Development Fund; Thailand Research Fund (TRF) [RSA5680041]
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WOS