• Ciprofloxacin Electrochemical Sensor Using Copper-Iron Mixed Metal Oxides Nanoparticles/Reduced Graphene Oxide Composite

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Document Title

Ciprofloxacin Electrochemical Sensor Using Copper-Iron Mixed Metal Oxides Nanoparticles/Reduced Graphene Oxide Composite

Author

Chuiprasert J., Srinives S., Boontanon N., Polprasert C., Ramungul N., Karawek A., Boontanon S.K.

Affiliations

Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand; School of Pharmacy, Walailak University, Nakhon Si Thammarat, 80161, Thailand; Laboratory for Pharmacogenomics, Division of Pharmacogenomics and Personalized Medicine, Somdech Phra Debaratana Medical Center, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand; Department of Medical Sciences, Ministry of Public Health, Nonthaburi, 11000, Thailand; National Biobank of Thailand, National Center for Genetic Engineering and Biotechnology, Pathum Thani12120, Thailand; Division of Clinical Chemistry, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand; Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand; Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, 10540, Thailand; Department of Pharmacy, University of Rajshahi, Rajshahi, 6205, Bangladesh; Pharmacogenomics Clinic, Bumrungrad Genomic Medicine Institute, Bumrungrad International Hospital, Bangkok, 10110, Thailand; Research and Development Laboratory, Bumrungrad International Hospital, Bangkok, 10110, Thailand; MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 3GL, United Kingdom; Faculty of Pharmaceutical Sciences, Burapha University, Chonburi20131, Thailand

Type

Article

Source Title

World Journal of Hepatology

ISSN

19485182

Year

2024

Volume

16

Issue

3

Page

366-378

Open Access

All Open Access, Gold

Publisher

Baishideng Publishing Group Inc

DOI

10.4254/wjh.v16.i3.366

Abstract

BACKGROUND The prevalence of metabolic-associated fatty liver disease (MAFLD) is a growing public health issue in people living with human immunodeficiency virus (PLWH). However, the pathophysiology of MAFLD is still unknown, and the role of genetic variables is only now becoming evident. AIM To evaluate the associations of gene-polymorphism-related MAFLD in PLWH. METHODS The study employed transient elastography with a controlled attenuation parameter ? 248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central Thailand. Candidate single-nucleotide poly-morphisms (SNPs) were genotyped using TaqMan? MGB probe 5' nuclease assays for seven MAFLD-related genes. Statistical analyses included SNP frequency analysis, Fisher's Exact and Chi-square tests, odds ratio calculations, and multivariable logistic regression. RESULTS The G-allele carriers of PNPLA3 (rs738409) exhibited a two-fold rise in MAFLD, increasing by 2.5 times in MAFLD with human immunodeficiency virus infection. The clinical features and genetic patterns imply that LEP rs7799039 A-allele carriers had a nine times (P = 0.001) more significant chance of developing aberrant triglyceride among PLWH. CONCLUSION The current study shows an association between PNPLA3 rs738409 and LEP rs7799039 with MAFLD in PLWH. ? The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

License

CC BY-NC

Rights

Authors

Publication Source

WoS

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