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Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
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Document Title
Cytotoxic and antimalarial alkaloids from the twigs of dasymaschalon obtusipetalum
Author
Jaidee A.,Promchai T.,Trisuwan K.,Laphookhieo S.,Rattanajak R.,Kamchonwongpaisan S.,Pyne S.G.,Ritthiwigrom T.
Name from Authors Collection
Affiliations
Department of Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai, 50200, Thailand; Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai, 57100, Thailand; Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Pathumthani, 12120, Thailand; School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
Type
Article
Source Title
Natural Product Communications
ISSN
1934578X
Year
2015
Volume
10
Issue
7
Open Access
All Open Access, Bronze, Green
Publisher
Natural Product Incorporation
DOI
10.1177/1934578x1501000709
Abstract
One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC50 values of 2.46±0.12 and 1.38±0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY-NC
Rights
SAGE Publishing
Publication Source
Scopus