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Cytotoxic cytochalasans from cultures of the fungus Metarhizium brunneum TBRC-BCC 79240
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Document Title
Cytotoxic cytochalasans from cultures of the fungus Metarhizium brunneum TBRC-BCC 79240
Author
Kornsakulkarn J., Auncharoen P., Khonsanit A., Boonyuen N., Thongpanchang C.
Affiliations
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand
Type
Article
Source Title
RSC Advances
ISSN
20462069
Year
2023
Volume
13
Issue
16
Page
10564-10576
Open Access
All Open Access, Gold, Green
Publisher
Royal Society of Chemistry
DOI
10.1039/d3ra00042g
Format
Abstract
Fourteen new cytochalasans, brunnesins A-N (1-14), along with eleven known compounds, were isolated from the culture extracts of the insect pathogenic fungus Metarhizium brunneum strain TBRC-BCC 79240. The compound structures were established by spectroscopy, X-ray diffraction analysis, and electronic circular dichroism. Compound 4 exhibited antiproliferative activity against all cell lines tested (mammalian), with 50% inhibition concentration (IC50) values ranging from 2.09 to 16.8 μg mL−1. Compounds 6 and 16 were shown to be bioactive only against non-cancerous Vero cells (IC50 4.03 and 0.637 μg mL−1, respectively) whereas compounds 9 and 12 were bioactive only against NCI-H187 small-cell lung cancer cells (IC50 18.59 and 18.54 μg mL−1, respectively). Compounds 7, 13, and 14 showed cytotoxicity against NCI-H187 and Vero cell lines with IC50 values ranging from 3.98-44.81 μg mL−1 © 2023 The Royal Society of Chemistry.
Funding Sponsor
National Science and Technology Development Agency; National Center for Genetic Engineering and Biotechnology
Publication Source
WOS