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Differential Impact of Plasma Proteins on the Adhesion Efficiency of Vascular-Targeted Carriers (VTCs) in Blood of Common Laboratory Animals
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Document Title
Differential Impact of Plasma Proteins on the Adhesion Efficiency of Vascular-Targeted Carriers (VTCs) in Blood of Common Laboratory Animals
Author
Namdee K., Sobczynski D.J., Onyskiw P.J., Eniola-Adefeso O.
Name from Authors Collection
Affiliations
Department of Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, United States; National Nanotechnology Center, National Science and Technology Development Agency, 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand
Type
Article
Source Title
Bioconjugate Chemistry
ISSN
10431802
Year
2015
Volume
26
Issue
12
Page
2419-2428
Open Access
All Open Access, Green
Publisher
American Chemical Society
DOI
10.1021/acs.bioconjchem.5b00474
Format
Abstract
Vascular-targeted carrier (VTC) interaction with human plasma is known to reduce targeted adhesion efficiency in vitro. However, the role of plasma proteins on the adhesion efficiency of VTCs in laboratory animals remains unknown. Here, in vitro blood flow assays are used to explore the effects of plasma from mouse, rabbit, and porcine on VTC adhesion. Porcine blood exhibited a strong negative plasma effect on VTC adhesion while no significant plasma effect was found with rabbit and mouse blood. A brush density poly(ethylene glycol) (PEG) on VTCs was effective at improving adhesion of microsized, but not nanosized, VTCs in porcine blood. Overall, the results suggest that porcine models, as opposed to mouse, can serve as better models in preclinical research for predicting the in vivo functionality of VTCs for use in humans. These considerations hold great importance for the design of various pharmaceutical products and development of reliable drug delivery systems. © 2015 American Chemical Society.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
Funding Sponsor
National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences
License
N/A
Rights
N/A
Publication Source
Scopus