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Effects of α-mangostin on embryonic development and liver development in zebrafish
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Metadata
Document Title
Effects of α-mangostin on embryonic development and liver development in zebrafish
Author
Pimtong W., Kitipaspallop W., Chun H.-S., Kim W.-K.
Name from Authors Collection
Affiliations
Nano Environmental and Health Safety Research Team, National Nanotechnology Center, National Science and Technology Development Agency, Khlong Luang, Pathum Thani 12120, Thailand; Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand; Biosystem Research Group, Korea Institute of Toxicology, Daejeon, 305-343, South Korea
Type
Article
Source Title
Molecular and Cellular Toxicology
ISSN
1738642X
Year
2020
Volume
16
Issue
4
Page
469-476
Open Access
Hybrid Gold
Publisher
Springer Verlag
DOI
10.1007/s13273-020-00099-1
Abstract
Background: Alpha-mangostin has potential as a chemopreventive agent but there is little information on its toxicological profile and developmental toxicity. Objective: We evaluated the effects of α-mangostin on embryonic development and hepatogenesis in zebrafish. Result: Exposure of embryos to 0.25–4 μM α-mangostin from 4–120 h post-fertilization (hpf) caused mortality of embryos with LC50 1.48 ± 0.29 μM. The compound also caused deformities, including head malformation, pericardial oedema, absence of swim bladder, yolk oedema, and bent tail. Exposure of zebrafish embryos to α-mangostin during early hepatogenesis (16–72 hpf) decreased the transcript expression levels of liver fatty acid-binding protein 10a (Fabp10a), but increased gene markers of inflammation, oxidative stress, and apoptosis. In Fabp10a:DsRed transgenic zebrafish, the intensity and the area of fluorescence in the liver of the treated group were decreased (non-significantly) relative to controls. Conclusion: These effects were more marked during early hepatogenesis (16–72 hpf) than during post-hepatogenesis (72–120 hpf). © 2020, The Author(s).
Keyword
Hepatogenesis | Toxicity | Xanthone | Zebrafish | α-Mangostin
Funding Sponsor
Korea Foundation for Advanced Studies
License
CC BY
Rights
Author
Publication Source
Scopus