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Endothelial Progenitor Cell Migration-Enhancing Factors in the Secretome of Placental-Derived Mesenchymal Stem Cells
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Document Title
Endothelial Progenitor Cell Migration-Enhancing Factors in the Secretome of Placental-Derived Mesenchymal Stem Cells
Author
Kamprom W.,Kheolamai P.,U-Pratya Y.,Supokawej A.,Wattanapanitch M.,Laowtammathron C.,Roytrakul S.,Issaragrisil S.
Name from Authors Collection
Affiliations
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand; Division of Cell Biology, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand; Center of Excellence in Stem Cell Research, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand; Division of Hematology, Department of Medicine, Mahidol University, Bangkok, 10700, Thailand; Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, 73170, Thailand; Proteomics Research Laboratory, Genome Institute, National Science and Technology Development Agency, Pathumthani, 12120, Thailand
Type
Article
Source Title
Stem Cells International
ISSN
16879678
Year
2016
Volume
2016
Open Access
All Open Access, Gold, Green
Publisher
Hindawi Limited
DOI
10.1155/2016/2514326
Abstract
Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues. We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type that plays an important role during the neovascularization. MSCs derived from placental tissues (PL-MSCs) significantly enhanced EPC migration while BM-MSCs, which are the standard source of MSCs for various clinical applications, did not. By using protein fractionation and mass spectrometry analysis, we identified several novel candidates for EPC migration enhancing factor in PL-MSCs secretome that could be used to enhance neovascularization in the injured/ischemic tissues. We recommend that the strategy developed in our study could be used to systematically identify therapeutically useful molecules in the secretomes of other MSC sources for the clinical applications. © 2016 Witchayaporn Kamprom et al.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY
Rights
Author
Publication Source
Scopus