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Fabrication of biocompatible magneto-fluorescence nanoparticles as a platform for fluorescent sensor and magnetic hyperthermia applications
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Metadata
Document Title
Fabrication of biocompatible magneto-fluorescence nanoparticles as a platform for fluorescent sensor and magnetic hyperthermia applications
Author
Sichamnan A., Yong N., Sillapaprayoon S., Pimtong W., Tang I.-M., Maneeprakorn W., Pon-On W.
Name from Authors Collection
Affiliations
Department of Physics, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand; Nano Environmental and Health Safety Research Team, National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand; Department of Physics, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand
Type
Article
Source Title
RSC Advances
ISSN
20462069
Year
2021
Volume
11
Issue
56
Page
35258-35267
Open Access
Gold
Publisher
Royal Society of Chemistry
DOI
10.1039/d1ra07389c
Abstract
Multifunctional nanoparticles with special magnetic and optical properties have been attracting a great deal of attention due to their important applications in the bioanalytical and biomedical fields. In this study, we report the fabrication of biocompatible magneto-fluorescence nanoparticles consisting of carbon dots (CDots) and silica-coated cobalt-manganese nanoferrites (Co0.5Mn0.5Fe2O4) (CoMnF@Si@CDots) (MagSiCDots) by a facile hydrothermal method. The as-prepared MagSiCDots have a particle size of 100-120 nm and show a negative zeta potential of -35.50 mV at a neutral pH. The fluorescence spectrum of the MagSiCDots nanoparticles consists of sharp excitation at 365 nm and broad blue light emission with a maximum wavelength of 442.5 nm and the MagSiCDots exhibit superparamagnetic behaviour with a saturation magnetization of 11.6 emu g-1. The potential of MagSiCDots as a fluorescent sensor and be used for magnetic hyperthermia applications. It is seen that the fluorescent intensity of a colloidal solution (a hydrogen sulfide (H2S) solution containing MagSiCDots nanoparticles) has a linear relationship with the H2S concentration range of 0.2-2 μM. The limit of detection (LOD) of H2S by our MagSiCDots particles is 0.26 μM and they remain stable for at least 90 min. To test the suitability of the MagSiCDots nanoparticles for use in hyperthermia application, induction heating using an AMF was done. It was observed that these nanoparticles had a specific absorption rate (SAR) of 28.25 W g-1. The in vitro and in vivo cytotoxicity of MagSiCDots were tested on HeLa cells lines. The results show a cell viability of about 85% when exposed to 100 μg mL-1 concentration of the particles. The in vivo cytotoxicity using zebrafish assay also confirmed the non-toxicity and biocompatibility of the nanoparticles to living cells. The reported data demonstrate that by combining CoMnF@Si and fluorescent CDots into a single system, not only nontoxic multifunctional nanomaterials but also multimodal nanoparticles for several applications, such as hazard gas detection and acting as a biocompatible heat source for therapeutic treatment of cancer, are provided. © The Royal Society of Chemistry.
Funding Sponsor
Thailand Graduate Institute of Science and Technology
License
CC BY-NC
Rights
Author
Publication Source
Scopus
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