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Facile preparation of aqueous-soluble fluorescent polyethylene glycol functionalized carbon dots from palm waste by one-pot hydrothermal carbonization for colon cancer nanotheranostics
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Metadata
Document Title
Facile preparation of aqueous-soluble fluorescent polyethylene glycol functionalized carbon dots from palm waste by one-pot hydrothermal carbonization for colon cancer nanotheranostics
Author
Sangjan A., Boonsith S., Sansanaphongpricha K., Thinbanmai T., Ratchahat S., Laosiripojana N., Wu K.C.-W., Shin H.S., Sakdaronnarong C.,
Name from Authors Collection
Scopus Author ID
57215876736
Scopus Author ID
56183758300
Scopus Author ID
57204761128
Scopus Author ID
57754798200
Scopus Author ID
57755795500
Affiliations
Department of Chemical Engineering, Faculty of Engineering, Mahidol University, 999 Putthamonthon 4 Road, Salaya, Nakorn Pathom, Putthamonthon, 73170, Thailand; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Pathum Thani, Khlong Luang, 12120, Thailand; The Joint Graduate School of Energy and Environment (JGSEE), King Mongkut’s University of Technology Thonburi, 126 Pracha Uthit Road, Bang Mot, Bangkok, Tungkru, 10140, Thailand; Department of Chemical Engineering, National Taiwan University, No.1, Sec.4 Roosevelt Road, Taipei, 10617, Taiwan; Center of Atomic Initiative for New Materials (AI-MAT), National Taiwan University, Taipei, 10617, Taiwan; International Graduate Program of Molecular Science and Technology, National Taiwan University (NTU-MST), Taipei, 10617, Taiwan; Department of Energy Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, South Korea; Department of Chemistry, UNIST, Ulsan, 44919, South Korea; Center for Multidimensional Carbon Materials, Institute of Basic Science (IBS), Ulsan, 44919, South Korea; Low Dimensional Carbon Material Center, UNIST, Ulsan, 44919, South Korea
Type
Article
Source Title
Scientific Reports
ISSN
20452322
Year
2022
Volume
12
Issue
1
Open Access
Gold, Green
Publisher
Nature Research
DOI
10.1038/s41598-022-14704-x
Format
Abstract
Carbon dots (CDs) are categorized as an emerging class of zero-dimension nanomaterials having high biocompatibility, photoluminescence, tunable surface, and hydrophilic property. CDs, therefore, are currently of interest for bio-imaging and nano-medicine applications. In this work, polyethylene glycol functionalized CDs (CD-PEG) were prepared from oil palm empty fruit bunch by a one-pot hydrothermal technique. PEG was chosen as a passivating agent for the enhancement of functionality and photoluminescence properties of CDs. To prepare the CDs-PEG, the effects of temperature, time, and concentration of PEG were investigated on the properties of CDs. The as-prepared CDs-PEG were characterized by several techniques including dynamic light scattering, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, fluorescence spectroscopy, Raman spectroscopy, Fourier-transform infrared spectroscopy and Thermogravimetric analysis. The as-prepared CDs under hydrothermal condition at 220 °C for 6 h had spherical morphology with an average diameter of 4.47 nm. Upon modification, CDs-PEG were photo-responsive with excellent photoluminescence property. The CDs-PEG was subsequently used as a drug carrier for doxorubicin [DOX] delivery to CaCo-2, colon cancer cells in vitro. DOX was successfully loaded onto CDs-PEG surface confirmed by FT-IR and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer (MALDI-TOF/MS) patterns. The selective treatment of CDs-PEG-DOX against the colorectal cancer cells, , relative to normal human fibroblast cells was succesfully demonstrated. © 2022, The Author(s).
Keyword
Caco-2 cell line | Caco-2 Cells | Carbon | chemistry | colon tumor | Colonic Neoplasms | Doxorubicin | fluorescent dye | Fluorescent Dyes | Fourier Transform Infrared | Human | Humans | infrared spectroscopy | macrogol | Polyethylene Glycols | Quantum dots | Spectroscopy | theranostic nanomedicine
Funding Sponsor
RSA6280074, RTA6280003; P1851609; National Research Council of Thailand
License
CC BY
Rights
Author
Publication Source
Scopus