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Formation of aggregates, icosahedral structures and percolation clusters of fullerenes in lipids bilayers: The key role of lipid saturation
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Document Title
Formation of aggregates, icosahedral structures and percolation clusters of fullerenes in lipids bilayers: The key role of lipid saturation
Author
Nisoh N, Jarerattanachat V, Karttunen M, Wong-ekkabut J
Name from Authors Collection
Affiliations
Kasetsart University; Kasetsart University; Kasetsart University; National Science & Technology Development Agency - Thailand; National Electronics & Computer Technology Center (NECTEC); Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario)
Type
Article
Source Title
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
ISSN
0005-2736
Year
2020
Volume
1862
Issue
9
Page
-
Open Access
Green Submitted, Bronze
Publisher
ELSEVIER
DOI
10.1016/j.bbamem.2020.183328
Format
Abstract
Carbon nanoparticles (CNPs) are attractive materials for a great number of applications but there are serious concerns regarding their influence on health and environment. Here, our focus is on the behavior of fullerenes in lipid bilayers with varying lipid saturations, chain lengths and fullerene concentrations using coarse-grained molecular dynamics (CG-MD) simulations. Our findings show that the lipid saturation level is a key factor in determining how fullerenes behave and where the fullerenes are located inside a lipid bilayer. In saturated and monounsaturated bilayers fullerenes aggregated and formed clusters with some of them showing icosahedral structures. In polyunsaturated lipid bilayers, no such structures were observed: In polyunsaturated lipid bilayers at high fullerene concentrations, connected percolation-like networks of fullerenes spanning the whole lateral area emerged at the bilayer center. In other systems only separate isolated aggregates were observed. The effects of fullerenes on lipid bilayers depend strongly on fullerene aggregation. When fullerenes aggregate, their interactions with the lipid tails change.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Funding Sponsor
Kasetsart University Research and Development Institute (KURDI); Faculty of Science at Kasetsart University; Thailand Science Research and Innovation (TSRI) [RSA6180021, PHD/0204/2559, PHD/0134/2561]; National Research Council of Thailand (NRCT) [RSA6180021, PHD/0204/2559, PHD/0134/2561]; Kasetsart University [RSA6180021, PHD/0204/2559, PHD/0134/2561]
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WOS