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Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis
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Document Title
Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis
Author
Auranwiwat C, Rattanajak R, Kamchonwongpaisan S, Laphookhieo S, Pyne SG, Limtharakul T
Name from Authors Collection
Affiliations
Chiang Mai University; Chiang Mai University; Chiang Mai University; University of Wollongong; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC); Mae Fah Luang University; Mae Fah Luang University; Chiang Mai University
Type
Article
Source Title
FITOTERAPIA
Year
2018
Volume
130
Page
198-202
Open Access
Green Submitted
Publisher
ELSEVIER SCIENCE BV
DOI
10.1016/j.fitote.2018.08.020
Format
Abstract
The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1-4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC50 values ranging from 21.0 +/- 3.10 - 33.7 +/- 7.69 and 21.0 +/- 5.44 - 43.5 +/- 11.9 mu M, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC50 values ranging from 0.60 +/- 0.17 - 4.91 +/- 2.69 mu M which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells.
Funding Sponsor
Thailand Research Fund; Office of the Higher Education Commission [MRG6180098]; Center of Excellence for Innovation in Chemistry (PERCH-CIC); Science Achievement Scholarship of Thailand (SAST); Graduate School of Chiang Mai University; bioassay laboratory, BIOTEC, NSTDA, Pathumthani, Thailand from NSTDA's Cluster Program Management
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Publication Source
WOS