• Hybrid immunity from SARS-CoV-2 infection and mRNA BNT162b2 vaccine among Thai school-aged children

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Document Title

Hybrid immunity from SARS-CoV-2 infection and mRNA BNT162b2 vaccine among Thai school-aged children

Author

Saraban K. Suntarattiwong P. Chantasrisawad N. Boonsathorn S. Kosalaraksa P. Phongsamart W. Tangsathapornpong A. Jaruampornpan P. Srisarang S. Puthanakit T.

Affiliations

Queen Sirikit National Institute of Child Health Bangkok Thailand; Department of Pediatrics Faculty of Medicine Chulalongkorn University Bangkok Thailand; Center of Excellence for Pediatric Infectious Diseases and Vaccines Faculty of Medicine Chulalongkorn University Bangkok Thailand; Thai Red Cross Emerging Infectious Diseases Clinical Center King Chulalongkorn Memorial Hospital Bangkok Thailand; Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand; Pediatric Infectious Disease Unit Faculty of Medicine Khon Kaen University Khon Kaen Thailand; Division of Infectious Diseases Department of Pediatrics Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand; Division of Infectious Diseases Department of Pediatrics Faculty of Medicine Thammasat University Pathum Thani Thailand; Virology and Cell Technology Research Team National Center for Genetic Engineering and Biotechnology (BIOTEC) National Science and Technology Development Agency (NSTDA) Pathum Thani Thailand

Type

Article

Source Title

Vaccine: X

ISSN

25901362

Year

2023

Volume

15

Open Access

All Open Access Gold Green

Publisher

Elsevier Ltd

DOI

10.1016/j.jvacx.2023.100414

Abstract

Objective: To compare the immune response of hybrid immunity � arising from SARS-CoV-2 infection and mRNA BNT162b2 vaccination � to that of 2-doses of vaccine. Methods: In a subanalysis of BNT162b2 vaccine trial in 5 to 11-year-old children There were 179 children who had hybrid immunity compared with 134 children with solely 2-dose vaccine. The immunological outcome was a surrogate virus neutralization test (sVNT) against the Omicron strain BA.1 (%inhibition). An sVNT level ?68 % inhibition was considered as protective immune response. Results: From February to April 2022 179 children had COVID-19 natural infection resulting in hybrid immunity included: Group1;prior vaccination(n = 17) Group2;after the first dose(n = 61) and Group3;after the second dose(n = 97). The proportion of children with protective immune response was higher in Group 3 and Group 1 � 61.9 % and 58.8 % compared to 36.1 % and 34.3 % in Group 2 and comparator group (2 doses of vaccine) respectively. The geometric mean % inhibition of sVNT was higher in Group 1 (68.5 95 %CI 55.5�.6) and Group 3 (63.5 95 %CI 55.5�.6) followed by comparator group (49.6 95 %CI 44.8�.9) and Group 2 (42.1 95 %CI 34.6�.3) p < 0.001. Conclusions: Immune response that arises from BNT162b2 vaccine after natural infection and infection after 2 doses of BNT162b2 was higher than infection after partially-vaccinated children. ? 2023 The Authors

License

CC BY-NC-ND

Rights

Authors

Publication Source

WOS

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