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Hydronaphthalenones and a Dihydroramulosin from the Endophytic Fungus PSU-N24
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Document Title
Hydronaphthalenones and a Dihydroramulosin from the Endophytic Fungus PSU-N24
Author
Sommart U, Rukachaisirikul V, Sukpondma Y, Phongpaichit S, Sakayaroj J, Kirtikara K
Name from Authors Collection
Affiliations
Prince of Songkla University; Prince of Songkla University; Prince of Songkla University; Prince of Songkla University; National Science & Technology Development Agency - Thailand; National Center Genetic Engineering & Biotechnology (BIOTEC)
Type
Article
Source Title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN
0009-2363
Year
2008
Volume
56
Issue
3
Open Access
Bronze
Publisher
PHARMACEUTICAL SOC JAPAN
DOI
10.1248/cpb.56.1687
Format
Abstract
Three new hydronaphthalenone derivatives (1-3) and one new dihydroramulosin derivative (4), were isolated from the endophytic fungus PSU-N24 together with eight known compounds. Their structures were elucidated by spectroscopic methods. Griseofulvin (9) displayed strong antifungal activity against Microsporum gypseum SH-MU-4 with a minimum inhibitory concentration (MIC) value of 2 mu g/ml while all metabolites exhibited very weak antibacterial activity (MIC value >= 128 mu g/ml) against Staphylococcus aureus, both standard and methicillin-resistant strains. 3-(2-Hydroxypropyl)benzene-1,2-diol (10) showed moderate antimalarial activity against Plasmodiun falciparum with an IC50 value of 6.68 mu g/ml. For antimycobacterial activity against Mycobacterium tuberculosis, compound 3 gave the best activity with the MIC value of 12.50 mu g/ml.
Funding Sponsor
Thailand Research Fund [PHD/0232/2549]; Center (PERCH-CIC), Commission on Higher Education (CHE-RG); Ministry of Education; Graduate School, Prince of Songkla University
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Publication Source
WOS