• Identification of Candidate Genes for Salt Tolerance at Seedling Stage in Rice Using QTL-Seq and Chromosome Segment Substitution Line-Derived Population

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Metadata

Document Title

Identification of Candidate Genes for Salt Tolerance at Seedling Stage in Rice Using QTL-Seq and Chromosome Segment Substitution Line-Derived Population

Author

Leawtrakun J., Aesomnuk W., Khanthong S., Dumhai R., Songtoasesakul D., Phosuwan S., Nuanpirom J., Charoensawan V., Siangliw J.L., Ruanjaichon V., Toojinda T., Wanchana S., Siangliw M., Arikit S.

Affiliations

Department of Basic Medical Sciences, Faculty of Medicine, Siam University, Bangkok, 10160, Thailand; Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Nakon Pathom, 73170, Thailand; Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand; Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand; Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, 10903, Thailand; National Nanotechnology Centre (NANOTEC), National Science and Technology Development Agency, Pathumthani, 12120, Thailand

Type

Article

Source Title

Pharmaceutics

ISSN

19994923

Year

2024

Volume

16

Issue

4

Open Access

All Open Access, Gold

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

DOI

10.3390/pharmaceutics16040514

Abstract

Diabetic Parkinson’s disease (DP) is a progressive neurodegenerative disease with metabolic syndrome that is increasing worldwide. Emerging research suggests that cannabidiol (CBD) is a neuropharmacological compound that acts against this disease, especially CBD in nano-formulation. The safety of cannabidiol lipid nanoparticles (CBD-LNP) was evaluated by assessing in vitro cytotoxicity in neurons and therapeutic outcomes in a DP animal model, including metabolic parameters and histopathology. CBD-LNPs were fabricated by using a microfluidization technique and showed significantly lower cytotoxicity than the natural form of CBD. The DP rats were induced by streptozotocin followed by a 4-week injection of MPTP with a high-fat diet. Rats were treated orally with a vehicle, CBD, CBD-LNP, or levodopa for 4 weeks daily. As a result, vehicle-treated rats exhibited metabolic abnormalities, decreased striatal dopamine levels, and motor and memory deficits. CBD-LNP demonstrated reduced lipid profiles, enhanced insulin secretion, and restored dopamine levels compared to CBD in the natural form. CBD-LNP also had comparable efficacy to levodopa in ameliorating motor deficits and memory impairment in behavior tests. Interestingly, CBD-LNP presented migration of damaged neuronal cells in the hippocampus more than levodopa. These findings suggest that CBD-LNP holds promise as an intervention addressing both metabolic and neurodegenerative aspects of DP, offering a potential therapeutic strategy. ? 2024 by the authors.

License

CC BY

Rights

Authors

Publication Source

WoS

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