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Immunogenicity and Reactogenicity of Messenger RNA Coronavirus Disease 2019 Vaccine Booster Administered by Intradermal or Intramuscular Route in Thai Older Adults
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Document Title
Immunogenicity and Reactogenicity of Messenger RNA Coronavirus Disease 2019 Vaccine Booster Administered by Intradermal or Intramuscular Route in Thai Older Adults
Author
Assantachai P. Niyomnaitham S. Chatthanawaree W. Intalapaporn S. Muangpaisan W. Phannarus H. Saichompoo R.B. Sura-Amonrattana U. Wongprompitak P. Toh Z.Q. Licciardi P.V. Srisutthisamphan K. Chokephaibulkit K.
Affiliations
Department of Preventive and Social Medicine Mahidol University Siriraj Hospital Bangkok Thailand; Department of Pharmacology Mahidol University Siriraj Hospital Bangkok Thailand; Siriraj Institute of Clinical Research Mahidol University Siriraj Hospital Bangkok Thailand; Department of Medicine Mahidol University Siriraj Hospital Bangkok Thailand; Department of Immunology Mahidol University Siriraj Hospital Bangkok Thailand; Infection and Immunity University of Melbourne Parkville VIC Australia; Department of Pediatrics University of Melbourne Parkville VIC Australia; National Center for Genetic Engineering and Biotechnology National Science Development Agency Pathum-thani Thailand; Department of Pediatrics Mahidol University Siriraj Hospital Bangkok Thailand
Type
Article
Source Title
Journal of Infectious Diseases
ISSN
221899
Year
2023
Volume
228
Issue
7
Page
868-877
Open Access
All Open Access Hybrid Gold Green
Publisher
Oxford University Press
DOI
10.1093/infdis/jiad133
Abstract
Background: Intradermal (ID) vaccination may alleviate COVID-19 vaccine shortages and vaccine hesitancy. Methods: Persons aged ?65 years who were vaccinated with 2-dose ChAdOx1 12-24 weeks earlier were randomized to receive a booster vaccination by either ID (20 ?g mRNA-1273 or 10 ?g BNT162b2) or intramuscular (IM) (100 ?g mRNA-1273 or 30 ?g BNT162b2) route. Anti-receptor-binding domain (RBD) immunoglobulin G (IgG) neutralizing antibody (NAb) and interferon gamma (IFN-?)-producing cells were measured at 2-4 weeks following vaccination. Results: Of 210 participants enrolled 70.5% were female and median age was 77.5 (interquartile range 71-84) years. Following booster dose both ID vaccinations induced 37% lower levels of anti-RBD IgG compared with IM vaccination of the same vaccine. NAb titers against ancestral and Omicron BA.1 were highest following IM mRNA-1273 (geometric mean 1718 and 617) followed by ID mRNA-1273 (1212 and 318) IM BNT162b2 (713 and 230) and ID BNT162b2 (587 and 148) respectively. Spike-specific IFN-?responses were similar or higher in the ID groups compared with IM groups. ID route tended to have fewer systemic adverse events (AEs) although more local AEs were reported in the ID mRNA-1273 group. Conclusions: Fractional ID vaccination induced lower humoral but comparable cellular immunity compared to IM and may be an alternative for older people. Clinical Trials Registration: TCTR20220112002. ? 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC-BY-NC-ND
Rights
Authors
Publication Source
WOS