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Impact of mAb-induced A475V substitution on viral fitness and antibody neutralization of SARS-CoV-2 omicron variants in the presence of monoclonal antibodies and human convalescent sera
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Document Title
Impact of mAb-induced A475V substitution on viral fitness and antibody neutralization of SARS-CoV-2 omicron variants in the presence of monoclonal antibodies and human convalescent sera
Author
Viriyakitkosol R., Wanitchang A., Srisutthisamphan K., Saenboonreung J., Boonkrai C., Pisitkun T., Jongkaewwattana A.
Affiliations
Virology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand; Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Type
Article
Source Title
Frontiers in Immunology
ISSN
16643224
Year
2023
Volume
14
Open Access
All Open Access|| Gold|| Green
Publisher
Frontiers Media SA
DOI
10.3389/fimmu.2023.1219546
Keyword
A-549 cell line | a475v gene | alkaline phosphatase | angiotensin converting enzyme 2 | Antibodies, Monoclonal | Article | binding affinity | Bioinformatics | breakthrough infection | controlled study | convalescence | convalescent serum | coronavirus disease 2019 | COVID-19 | COVID-19 convalescent plasma treatment | COVID-19 Serotherapy | cytopathogenic effect | enzyme linked immunosorbent assay | fluorescence microscopy | gene | genetic transfection | HEK293T cell line | Human | human cell | Humans | immunofluorescence assay | luciferase assay | Monoclonal antibody | Pandemic | peripheral blood mononuclear cell | Receptor binding domain | SARS-CoV-2 | SARS-CoV-2 (lineage BA.2) | SARS-CoV-2 antibody | SARS-CoV-2 Omicron | SARS-CoV-2 variants | Severe acute respiratory syndrome coronavirus 2 | site directed mutagenesis | unclassified drug | viral protein | virus neutralization | Virus replication | virus spike protein | virus transmission | Western blotting
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY
Rights
Authors
Publication Source
WOS