Marine Streptomyces chumphonensis KK1-2(T) produces piericidin A1 as the major secondary metabolite

Abstract

Strain KK1-2(T) is the type strain of marine Streptomyces chomphonensis. Since the discovery of this Streptomyces species, the secondary metabolite of the type strain has not been characterized. Based on genome sequence analysis, the biosynthetic gene cluster of piericidin A1 was detected in the genome of strain KK1-2(T). The isolation of secondary metabolites and spectroscopy data confirm the chemical structure of piericidin A1 produced by the type strain. This study is the first report of the genome analysis and the secondary metabolite produced by the type strain of S. chumphonensis.