• Menthol induces extracellular vesicle regulation of apoptosis via ATG3 and caspase-3 in acute leukemic cells

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Document Title

Menthol induces extracellular vesicle regulation of apoptosis via ATG3 and caspase-3 in acute leukemic cells

Author

Charoensedtasin K., Naksawat M., Norkaew C., Kheansaard W., Roytrakul S., Tanyong D.

Affiliations

Department of Agro-Industrial, Food, and Environmental Technology, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok, 10800, Thailand; Functional Proteomics Technology Laboratory, National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand; Food and Agro-Industry Research Center, King Mongkut’s University of Technology North Bangkok, Bangkok, 10800, Thailand; Center for Food Industry Innovation Technology, King Mongkut’s University of Technology North Bangkok, Bangkok, 10800, Thailand; Department of Biotechnology, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok, 10800, Thailand; Research Group for Food Production Engineering, National Food Institute, Technical University of Denmark, Kongens Lyngby28000, Denmark

Type

Article

Source Title

Gels

ISSN

23102861

Year

2024

Volume

10

Issue

4

Open Access

All Open Access, Gold

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

DOI

10.3390/gels10040271

Abstract

Due to its excellent biocompatibility and ease of biodegradation, jellyfish gelatin has gained attention as a hydrogel. However, hydrogel produced from jellyfish gelatin has not yet been sufficiently characterized. Therefore, this research aims to produce a jellyfish gelatin-based hydrogel. The gelatin produced from desalted jellyfish by-products varied with the part of the specimen and extraction time. Hydrogels with gelatin: glutaraldehyde ratios of 10:0.25, 10:0.50, and 10:1.00 (v/v) were characterized, and their cefazolin release ability was determined. The optimal conditions for gelatin extraction and chosen for the development of jellyfish hydrogels (JGel) included the use of the umbrella part of desalted jellyfish by-products extracted for 24 h (WU24), which yielded the highest gel strength (460.02 g), viscosity (24.45 cP), gelling temperature (12.70 ?C), and melting temperature (22.48 ?C). The quantities of collagen alpha?1(XXVIII) chain A, collagen alpha?1(XXI) chain, and collagen alpha?2(IX) chain in WU24 may influence its gel properties. Increasing the glutaraldehyde content in JGel increased the gel fraction by decreasing the space between the protein chains and gel swelling, as glutaraldehyde binds with lateral amino acid residues and produces a stronger network. At 8 h, more than 80% of the cefazolin in JGel (10:0.25) was released, which was higher than that released from bovine hydrogel (52.81%) and fish hydrogel (54.04%). This research is the first report focused on the production of JGel using glutaraldehyde as a cross-linking agent. ? 2024 by the authors.

License

CC BY

Rights

Authors

Publication Source

WoS

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