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Phytosterol, lipid and phenolic composition, and biological activities of guava seed oil
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Metadata
Document Title
Phytosterol, lipid and phenolic composition, and biological activities of guava seed oil
Author
Prommaban A.,Utama-Ang N.,Chaikitwattana A.,Uthaipibull C.,Porter J.B.,Srichairatanakool S.
Name from Authors Collection
Affiliations
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Product Development Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Herb and Extract Business Development, Tipco Biotech Company, Prachuapkhirikhan, 77000, Thailand; Protein-Ligand Engineering and Molecular Biology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, Thailand; Department of Haematology, O’Gormond Building, Institute of Cancer Research, University College London, Huntley Street, London, WC1E 6BT, United Kingdom
Type
Article
Source Title
Molecules
ISSN
14203049
Year
2020
Volume
25
Issue
11
Open Access
All Open Access, Gold, Green
Publisher
MDPI AG
DOI
10.3390/molecules25112474
Abstract
Plant seeds have been found to contain bioactive compounds that have potential nutraceutical benefits. Guava seeds (Psidium guajava) are by-products in the beverage and juice industry; however, they can be utilized for a variety of commercial purposes. This study was designed to analyze the phytochemicals of the n-hexane extract of guava seed oil (GSO), to study its free-radical scavenging activity, and to monitor the changes in serum lipids and fatty acid profiles in rats that were fed GSO. The GSO was analyzed for phytochemicals using chromatographic methods. It was also tested for free-radical scavenging activity in hepatoma and neuroblastoma cells, and analyzed in terms of serum lipids and fatty acids. GSO was found to contain phenolic compounds (e.g., chlorogenic acid and its derivatives) and phytosterols (e.g., stimasterol, β-sitosterol and campesterol), and exerted radical-scavenging activity in cell cultures in a concentration-dependent manner. Long-term consumption of GSO did not increase cholesterol and triglyceride levels in rat serum, but it tended to decrease serum fatty acid levels in a concentration-dependent manner. This is the first study to report on the lipid, phytosterol and phenolic compositions, antioxidant activity, and the hepato- and neuro-protection of hydrogen peroxide-induced oxidative stress levels in the GSO extract. © 2020 by the authors.
Keyword
Antioxidant | Hexane extract | Lipid | Phenolic compounds | Phytosterols | Psidium guajava | Seed
Industrial Classification
Knowledge Taxonomy Level 1
Knowledge Taxonomy Level 2
Knowledge Taxonomy Level 3
License
CC BY
Rights
Author
Publication Source
Scopus